scholarly journals Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex

2002 ◽  
Vol 99 (2) ◽  
pp. 1041-1046 ◽  
Author(s):  
J. J. Renger ◽  
K. N. Hartman ◽  
Y. Tsuchimoto ◽  
M. Yokoi ◽  
S. Nakanishi ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Long Term Depression ◽  
Dependent Plasticity ◽  
Metabotropic Glutamate

Group 2 metabotropic glutamate receptors induced long term depression in mouse striatal slices

2001 ◽  
Vol 316 (3) ◽  
pp. 178-182 ◽  
Author(s):  
Laetitia Kahn ◽  
Gérard Alonso ◽  
David Robbe ◽  
Joël Bockaert ◽  
Olivier J. Manzoni
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Long Term Depression ◽  
Striatal Slices ◽  
Metabotropic Glutamate ◽  
Group 2

Induction of NMDA Receptor-Dependent Long-Term Depression in Visual Cortex Does Not Require Metabotropic Glutamate Receptors

1999 ◽  
Vol 82 (6) ◽  
pp. 3594-3597 ◽  
Author(s):  
Nathaniel B. Sawtell ◽  
Kimberly M. Huber ◽  
John C. Roder ◽  
Mark F. Bear
Keyword(s):  
Visual Cortex ◽  
Nmda Receptor ◽  
Metabotropic Glutamate Receptors ◽  
Low Frequency ◽  
Long Term Depression ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Frequency Stimulation ◽  
Visual Cortical

We tested the role of group I mGluRs in the induction of long-term depression (LTD) in the visual cortex, using the novel mGluR antagonist LY341495 and mice lacking mGluR5, the predominant phosphoinositide (PI)-linked mGluR in the visual cortex. We find that LY341495 is a potent blocker of glutamate-stimulated PI hydrolysis in visual cortical synaptoneurosomes, and that it effectively antagonizes the actions of the mGluR agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on synaptic transmission in visual cortical slices. However, LY341495 has no effect on the induction of LTD by low-frequency stimulation. Furthermore, mice lacking mGluR5 show normal NMDA receptor-dependent LTD. These results indicate that group I mGluR activation is not required for the induction of NMDA receptor-dependent LTD in the visual cortex.

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