scholarly journals Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex

2015 ◽  
Vol 112 (41) ◽  
pp. 12852-12857 ◽  
Author(s):  
Michael S. Sidorov ◽  
Eitan S. Kaplan ◽  
Emily K. Osterweil ◽  
Lothar Lindemann ◽  
Mark F. Bear
Keyword(s):  
Visual Cortex ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Ocular Dominance ◽  
Monocular Deprivation ◽  
Excitatory Synapses ◽  
Ocular Dominance Plasticity ◽  
Metabotropic Glutamate

A feature of early postnatal neocortical development is a transient peak in signaling via metabotropic glutamate receptor 5 (mGluR5). In visual cortex, this change coincides with increased sensitivity of excitatory synapses to monocular deprivation (MD). However, loss of visual responsiveness after MD occurs via mechanisms revealed by the study of long-term depression (LTD) of synaptic transmission, which in layer 4 is induced by acute activation of NMDA receptors (NMDARs) rather than mGluR5. Here we report that chronic postnatal down-regulation of mGluR5 signaling produces coordinated impairments in both NMDAR-dependent LTD in vitro and ocular dominance plasticity in vivo. The data suggest that ongoing mGluR5 signaling during a critical period of postnatal development establishes the biochemical conditions that are permissive for activity-dependent sculpting of excitatory synapses via the mechanism of NMDAR-dependent LTD.

scholarly journals The modulation of Group I metabotropic glutamate receptor on synaptic transmission efficiency in the Primary Visual Cortex of Monocular Deprivation Amblyopia Rat

2019 ◽  
Author(s):  
XiangLing Liu ◽  
Rui Zhang ◽  
ZiXuan Song ◽  
JingLi Wang ◽  
Li Zhang ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Synaptic Transmission ◽  
Glutamate Receptor ◽  
Primary Visual Cortex ◽  
Metabotropic Glutamate Receptor ◽  
Transmission Efficiency ◽  
Monocular Deprivation ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Fepsp Slope

Abstract Background :The occurrence of amblyopia is closely related to the glutamate receptors in visual cortex. The expression of metabotropic glutamate receptor 1 (mGluR1) in the visual cortex of rats with amblyopia has been proved to decrease, however, the role of mGluR1 in the synaptic transmission of visual cortex is not clear. This study aimed to investigate the effect of group I mGluR on the synaptic transmission efficiency in the primary visual cortex of monocular deprivation amblyopia rat. Methods The 14-day-old rads were rangomly divided intonormal control group and form-deprivation group,with 8 rats in each group. The eyelids of the left eye were sutured to establish the monocular form- deprivation amblyopia rat model,The rats visual cortex slices were prepared and incubated in artificial cerebrospinal fluid . Four groups of drugs that it is 3,5-dihydroxyphenylglycine( DHPG), LY367385, 2-methyl-6( phenyl acetylene) pyridine hydrochloride( MPEP) and DHPG, LY367385and MPEP and DHPG were added to every group, respectively.The extracellular recording technique was used to record the field excitatory postsynaptic potential (fEPSP) in the visual cortex. Results: After application of DHPG, the fEPSP-slope of the visual cortex was significantly increased in both normal rats and monocular deprivation amblyopia rats (P<0.001), but the increase of normal group was significantly higher than that of amblyopia group (P<0.05). Application of LY367385, a selective mGluR1 blocker or Application of MPEP, an mGluR5 blocker can partially reduce the DHPG-induced fEPSP-slope in both normal group and amblyopia group. Conclusions:These results demonstrate that the effect of modulation of group I mGluR (mGluR1, 5) on the synaptic transmission was reduced in the visual cortex of monocular deprivation amblyopia rat. found that agonist DHPG of Group I mGluRs increased synaptic transmission efficiency of neurons in visual cortex of normal rats and monocular form deprivation rats.

scholarly journals Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction

2015 ◽  
Vol 112 (4) ◽  
pp. 1196-1201 ◽  
Author(s):  
Adam G. Walker ◽  
Cody J. Wenthur ◽  
Zixiu Xiang ◽  
Jerri M. Rook ◽  
Kyle A. Emmitte ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fear Extinction ◽  
Long Term Depression ◽  
Metabotropic Glutamate ◽  
Metabotropic Glutamate Receptor 3

Clinical studies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect performance on cognitive tasks dependent upon the prefrontal cortex (PFC) and may be linked to psychiatric conditions such as schizophrenia, bipolar disorder, and addiction. We have performed a series of studies aimed at understanding how mGlu3 influences PFC function and cognitive behaviors. In the present study, we found that activation of mGlu3 can induce long-term depression in the mouse medial PFC (mPFC) in vitro. Furthermore, in vivo administration of a selective mGlu3 negative allosteric modulator impaired learning in the mPFC-dependent fear extinction task. The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition. Additionally, potentiators of mGlu3 may be useful in alleviating prefrontal impairments associated with several CNS disorders.

In vitro and in vivo evaluation of [18F]-FDEGPECO as a PET tracer for imaging the metabotropic glutamate receptor subtype 5 (mGluR5)

NeuroImage ◽  
2011 ◽  
Vol 56 (3) ◽  
pp. 984-991 ◽  
Author(s):  
Cindy A. Wanger-Baumann ◽  
Linjing Mu ◽  
Michael Honer ◽  
Sara Belli ◽  
Malte F. Alf ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Subtype ◽  
In Vivo Evaluation ◽  
Metabotropic Glutamate ◽  
Pet Tracer
Sign in / Sign up

Export Citation Format

Share Document