scholarly journals Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles

2014 ◽  
Vol 40 (3) ◽  
pp. 755-765 ◽  
Author(s):  
Jerri M Rook ◽  
Mohammed N Tantawy ◽  
Mohammad S Ansari ◽  
Andrew S Felts ◽  
Shaun R Stauffer ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Occupancy ◽  
Receptor Subtype ◽  
Allosteric Modulators ◽  
Metabotropic Glutamate ◽  
In Vitro Binding ◽  
Vitro Binding

In vitro binding of a radio-labeled positive allosteric modulator for metabotropic glutamate receptor subtype 5

Synapse ◽  
2012 ◽  
Vol 67 (3) ◽  
pp. 135-144 ◽  
Author(s):  
John R. Zysk ◽  
Nathan Spear ◽  
William Fieles ◽  
Mark M. Stein ◽  
Linda S. Sygowski ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Subtype ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Metabotropic Glutamate ◽  
In Vitro Binding ◽  
Vitro Binding

In vitro and in vivo evaluation of [18F]-FDEGPECO as a PET tracer for imaging the metabotropic glutamate receptor subtype 5 (mGluR5)

NeuroImage ◽  
2011 ◽  
Vol 56 (3) ◽  
pp. 984-991 ◽  
Author(s):  
Cindy A. Wanger-Baumann ◽  
Linjing Mu ◽  
Michael Honer ◽  
Sara Belli ◽  
Malte F. Alf ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Subtype ◽  
In Vivo Evaluation ◽  
Metabotropic Glutamate ◽  
Pet Tracer

In Vitro Binding Characteristics of a New Selective Group II Metabotropic Glutamate Receptor Radioligand, [3H]LY354740, in Rat Brain

1998 ◽  
Vol 53 (2) ◽  
pp. 228-233 ◽  
Author(s):  
Hervé Schaffhauser ◽  
J. Grayson Richards ◽  
Jayne Cartmell ◽  
Sylvie Chaboz ◽  
John A. Kemp ◽  
...  
Keyword(s):  
Rat Brain ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Binding Characteristics ◽  
Metabotropic Glutamate ◽  
In Vitro Binding ◽  
Vitro Binding ◽  
Group Ii
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