scholarly journals Modulation of Glutamine Synthetase Adenylylation and Deadenylylation Is Mediated by Metabolic Transformation of the PII-Regulatory Protein

1971 ◽  
Vol 68 (12) ◽  
pp. 2949-2953 ◽  
Author(s):  
M. S. Brown ◽  
A. Segal ◽  
E. R. Stadtman
1993 ◽  
Vol 294 (3) ◽  
pp. 813-819 ◽  
Author(s):  
R Varón-Castellanos ◽  
B H Havsteen ◽  
M García-Moreno ◽  
E Valero-Ruiz ◽  
M Molina-Alarcón ◽  
...  

A kinetic analysis of the glutamine synthetase bicyclic cascade is presented. It includes the dependence on time from the onset of the reaction of both the uridylylation of Shapiro's regulatory protein and the adenylylation of the glutamine synthetase. The transient phase equations obtained allow an estimation of the time elapsed until the states of uridylylation and adenylylation reach their steady-states, and therefore an evaluation of the effective sensitivity of the system. The contribution of the uridylylation cycle to the adenylylation cycle has been studied, and an equation relating the state of adenylylation at any time to the state of uridylylation at the same instant has been derived.


1995 ◽  
Vol 132 (1-2) ◽  
pp. 153-157 ◽  
Author(s):  
Wally C. Heeswijk ◽  
Brenda Stegeman ◽  
Sjouke Hoving ◽  
Douwe Molenaar ◽  
Daniel Kahn ◽  
...  

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