scholarly journals Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.

1977 ◽  
Vol 74 (3) ◽  
pp. 1147-1151 ◽  
Author(s):  
U. Francke ◽  
M. A. Pellegrino
Keyword(s):  
Major Histocompatibility Complex ◽  
Human Chromosome ◽  
Chromosome 6 ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Human Chromosome 6

Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei

2000 ◽  
Vol 113 (9) ◽  
pp. 1565-1576 ◽  
Author(s):  
E.V. Volpi ◽  
E. Chevret ◽  
T. Jones ◽  
R. Vatcheva ◽  
J. Williamson ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Large Scale ◽  
Gene Clusters ◽  
Cell Types ◽  
Chromatin Organization ◽  
Chromosome 6 ◽  
Chromatin Loop ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Genomic Regions

The large-scale chromatin organization of the major histocompatibility complex and other regions of chromosome 6 was studied by three-dimensional image analysis in human cell types with major differences in transcriptional activity. Entire gene clusters were visualized by fluorescence in situ hybridization with multiple locus-specific probes. Individual genomic regions showed distinct configurations in relation to the chromosome 6 terrritory. Large chromatin loops containing several megabases of DNA were observed extending outwards from the surface of the domain defined by the specific chromosome 6 paint. The frequency with which a genomic region was observed on an external chromatin loop was cell type dependent and appeared to be related to the number of active genes in that region. Transcriptional up-regulation of genes in the major histocompatibility complex by interferon-gamma led to an increase in the frequency with which this large gene cluster was found on an external chromatin loop. Our data are consistent with an association between large-scale chromatin organization of specific genomic regions and their transcriptional status.

The human α2(XI) collagen gene (COL11A2) maps to the centromeric border of the major histocompatibility complex on chromosome 6

Genomics ◽  
1989 ◽  
Vol 5 (4) ◽  
pp. 925-931 ◽  
Author(s):  
Isabel M. Hanson ◽  
Patricia Gorman ◽  
Vincent C.H. Lui ◽  
Kathryn S.E. Cheah ◽  
Ellen Solomon ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Chromosome 6 ◽  
Collagen Gene ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

Orientation of major histocompatibility (MHC) genes relative to the centromere of human chromosome 6

2008 ◽  
Vol 15 (2) ◽  
pp. 198-202 ◽  
Author(s):  
E. Barker ◽  
P. L. Pearson ◽  
P. Meera Khan ◽  
G. M. TH. Schreuder ◽  
K. Madan
Keyword(s):  
Human Chromosome ◽  
Chromosome 6 ◽  
Major Histocompatibility ◽  
Mhc Genes ◽  
Human Chromosome 6
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