Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase.

J. J. Chen; M. S. Throop; L. Gehrke; I. Kuo; J. K. Pal; M. Brodsky; I. M. London

doi:10.1073/pnas.88.17.7729

Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.88.17.7729 ◽

1991 ◽

Vol 88 (17) ◽

pp. 7729-7733 ◽

Cited By ~ 125

Author(s):

J. J. Chen ◽

M. S. Throop ◽

L. Gehrke ◽

I. Kuo ◽

J. K. Pal ◽

...

Keyword(s):

Protein Kinase ◽

Initiation Factor ◽

Eukaryotic Initiation Factor ◽

Double Stranded Rna ◽

Eukaryotic Initiation Factor 2 ◽

Initiation Factor 2 ◽

Rabbit Reticulocytes

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Phosphorylation of Plant Eukaryotic Initiation Factor-2 by the Plant-encoded Double-stranded RNA-dependent Protein Kinase, pPKR, and Inhibition of Protein Synthesisin Vitro

Journal of Biological Chemistry ◽

10.1074/jbc.271.8.4539 ◽

1996 ◽

Vol 271 (8) ◽

pp. 4539-4544 ◽

Cited By ~ 41

Author(s):

Jeffrey O. Langland ◽

Lisa A. Langland ◽

Karen S. Browning ◽

Don A. Roth

Keyword(s):

Protein Kinase ◽

Initiation Factor ◽

Eukaryotic Initiation Factor ◽

Dependent Protein Kinase ◽

Double Stranded Rna ◽

Eukaryotic Initiation Factor 2 ◽

Initiation Factor 2 ◽

Dependent Protein

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Nuclear Factor 90 Is a Substrate and Regulator of the Eukaryotic Initiation Factor 2 Kinase Double-stranded RNA-activated Protein Kinase

Journal of Biological Chemistry ◽

10.1074/jbc.m104408200 ◽

2001 ◽

Vol 276 (35) ◽

pp. 32522-32530 ◽

Cited By ~ 66

Author(s):

Lisa M. Parker ◽

Ivo Fierro-Monti ◽

Michael B. Mathews

Keyword(s):

Protein Kinase ◽

Initiation Factor ◽

Nuclear Factor ◽

Eukaryotic Initiation Factor ◽

Double Stranded Rna ◽

Eukaryotic Initiation Factor 2 ◽

Initiation Factor 2

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The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.

Journal of Virology ◽

10.1128/jvi.66.4.1943-1950.1992 ◽

1992 ◽

Vol 66 (4) ◽

pp. 1943-1950 ◽

Cited By ~ 120

Author(s):

M V Davies ◽

O Elroy-Stein ◽

R Jagus ◽

B Moss ◽

R J Kaufman

Keyword(s):

Protein Kinase ◽

Vaccinia Virus ◽

Gene Product ◽

Initiation Factor ◽

Alpha Subunit ◽

Eukaryotic Initiation Factor ◽

Double Stranded Rna ◽

Eukaryotic Initiation Factor 2 ◽

Initiation Factor 2

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In situ phosphorylation of the subunit of eukaryotic initiation factor 2 in reticulocyte lysates inhibited by heme deficiency, double-stranded RNA, oxidized glutathione, or the heme-regulated protein kinase

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.76.5.2118 ◽

1979 ◽

Vol 76 (5) ◽

pp. 2118-2122 ◽

Cited By ~ 46

Author(s):

V. Ernst ◽

D. H. Levin ◽

I. M. London

Keyword(s):

Protein Kinase ◽

Initiation Factor ◽

Oxidized Glutathione ◽

Eukaryotic Initiation Factor ◽

Double Stranded Rna ◽

Eukaryotic Initiation Factor 2 ◽

Initiation Factor 2 ◽

Reticulocyte Lysates

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Regulation of protein synthesis: Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.75.3.1121 ◽

1978 ◽

Vol 75 (3) ◽

pp. 1121-1125 ◽

Cited By ~ 129

Author(s):

D. Levin ◽

I. M. London

Keyword(s):

Protein Synthesis ◽

Protein Kinase ◽

Initiation Factor ◽

Eukaryotic Initiation Factor ◽

Double Stranded Rna ◽

Eukaryotic Initiation Factor 2 ◽

Initiation Factor 2

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Okadaic Acid Induces Apoptosis through Double-Stranded RNA-Dependent Protein Kinase/Eukaryotic Initiation Factor-2 Pathway in Human Osteoblastic MG63 Cells

The Journal of Biochemistry ◽

10.1093/jb/mvh144 ◽

2004 ◽

Vol 136 (4) ◽

pp. 433-438 ◽

Cited By ~ 24

Author(s):

H. Morimoto

Keyword(s):

Protein Kinase ◽

Okadaic Acid ◽

Initiation Factor ◽

Eukaryotic Initiation Factor ◽

Dependent Protein Kinase ◽

Double Stranded Rna ◽

Mg63 Cells ◽

Eukaryotic Initiation Factor 2 ◽

Initiation Factor 2 ◽

Dependent Protein

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Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression ◽

10.1016/0167-4781(94)90229-1 ◽

1994 ◽

Vol 1219 (3) ◽

pp. 693-696 ◽

Cited By ~ 13

Author(s):

Harry Mellor ◽

Kevin M. Flowers ◽

Scot R. Kimball ◽

Leonard S. Jefferson

Keyword(s):

Initiation Factor ◽

Eukaryotic Initiation Factor ◽

Double Stranded Rna ◽

Eukaryotic Initiation Factor 2 ◽

Initiation Factor 2

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Inhibition of protein synthesis initiation by oxidized glutathione: Activation of a protein kinase that phosphorylates the subunit of eukaryotic initiation factor 2

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.75.9.4110 ◽

1978 ◽

Vol 75 (9) ◽

pp. 4110-4114 ◽

Cited By ~ 63

Author(s):

V. Ernst ◽

D. H. Levin ◽

I. M. London

Keyword(s):

Protein Synthesis ◽

Protein Kinase ◽

Initiation Factor ◽

Oxidized Glutathione ◽

Eukaryotic Initiation Factor ◽

Eukaryotic Initiation Factor 2 ◽

Inhibition Of Protein Synthesis ◽

Initiation Factor 2 ◽

Protein Synthesis Initiation

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Correlation between the distribution of the reversing factor and eukaryotic initiation factor 2 in heme-deficient or double-stranded RNA-inhibited reticulocyte lysates

FEBS Letters ◽

10.1016/0014-5793(88)80310-7 ◽

1988 ◽

Vol 236 (1) ◽

pp. 179-184 ◽

Cited By ~ 8

Author(s):

Robert L. Matts ◽

N.Shaun B. Thomas ◽

Robin Hurst ◽

Irving M. London

Keyword(s):

Initiation Factor ◽

Eukaryotic Initiation Factor ◽

Double Stranded Rna ◽

Eukaryotic Initiation Factor 2 ◽

Initiation Factor 2 ◽

Reticulocyte Lysates

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Regulation of double-stranded RNA-activated eukaryotic initiation factor 2 kinase by type 2 protein phosphatase in reticulocyte lysates

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.79.21.6512 ◽

1982 ◽

Vol 79 (21) ◽

pp. 6512-6516 ◽

Cited By ~ 12

Author(s):

R. Petryshyn ◽

D. H. Levin ◽

I. M. London

Keyword(s):

Protein Phosphatase ◽

Initiation Factor ◽

Eukaryotic Initiation Factor ◽

Double Stranded Rna ◽

Eukaryotic Initiation Factor 2 ◽

Initiation Factor 2 ◽

Reticulocyte Lysates

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