scholarly journals Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove

1999 ◽  
Vol 96 (13) ◽  
pp. 7196-7201 ◽  
Author(s):  
Y. Takebayashi ◽  
P. Pourquier ◽  
A. Yoshida ◽  
G. Kohlhagen ◽  
Y. Pommier
Keyword(s):  
Anticancer Drug ◽  
Topoisomerase I ◽  
Minor Groove ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Ecteinascidin 743 ◽  
Human Dna Topoisomerase I

DNA Minor Groove Binding-Directed Poisoning of Human DNA Topoisomerase I by Terbenzimidazoles†

Biochemistry ◽  
1998 ◽  
Vol 37 (10) ◽  
pp. 3558-3566 ◽  
Author(s):  
Zhitao Xu ◽  
Tsai-Kun Li ◽  
Jung Sun Kim ◽  
Edmond J. LaVoie ◽  
Kenneth J. Breslauer ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Minor Groove ◽  
Dna Topoisomerase I ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Topoisomerase ◽  
Dna Minor Groove ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Minor Groove-Directed and Intercalative Ligand−DNA Interactions in the Poisoning of Human DNA Topoisomerase I by Protoberberine Analogs†

Biochemistry ◽  
1997 ◽  
Vol 36 (41) ◽  
pp. 12542-12553 ◽  
Author(s):  
Daniel S. Pilch ◽  
Chiang Yu ◽  
Darshan Makhey ◽  
Edmond J. LaVoie ◽  
A. R. Srinivasan ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Minor Groove ◽  
Dna Topoisomerase I ◽  
Dna Interactions ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I

scholarly journals Human DNA-topoisomerase I activity is affected by bis-netropsin's binding to DNA minor groove

IUBMB Life ◽  
1998 ◽  
Vol 44 (5) ◽  
pp. 997-1010
Author(s):  
Alyona Sukhanova ◽  
Sergei Grokhovsky ◽  
Alexei Zhuze ◽  
David Roper ◽  
Igor Bronstein
Keyword(s):  
Topoisomerase I ◽  
Minor Groove ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Dna Minor Groove ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Human DNA topoisomerase I: An anticancer drug target present in human sarcomas

2002 ◽  
Vol 33 (6) ◽  
pp. 599-607 ◽  
Author(s):  
Landon W. Coleman ◽  
L.Ralph Rohr ◽  
Igor B. Bronstein ◽  
Joseph A. Holden
Keyword(s):  
Anticancer Drug ◽  
Drug Target ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Inhibition of Human DNA Topoisomerase I by New DNA Minor Groove Ligands: Derivatives of Oligo-1,3-Thiazolecarboxamides

2001 ◽  
Vol 11 (3) ◽  
pp. 137-147 ◽  
Author(s):  
Dmitry V. Bugreev ◽  
Elena L. Vasyutina ◽  
Vladimir A. Ryabinin ◽  
Alexander N. Sinyakov ◽  
Valentina N. Buneva ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Minor Groove ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Dna Minor Groove ◽  
Human Dna ◽  
Derivatives Of ◽  
Human Dna Topoisomerase I

Isodiospyrin as a novel human DNA topoisomerase I inhibitor

2003 ◽  
Vol 66 (10) ◽  
pp. 1981-1991 ◽  
Author(s):  
Chun-Yuan Ting ◽  
Chia-Tse Hsu ◽  
Hsiang-Ting Hsu ◽  
Jin-Shan Su ◽  
Tzong-Yueh Chen ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(ii) complex of purpurin: dual poison for human DNA topoisomerase I and II

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59344-59357 ◽  
Author(s):  
Piyal Das ◽  
Chetan Kumar Jain ◽  
Sanjoy K. Dey ◽  
Rajat Saha ◽  
Abhishek Dutta Chowdhury ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Topoisomerase I ◽  
Dna Interaction ◽  
Dna Topoisomerase I ◽  
Oxygen Species ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Anti Tumor Activity ◽  
Human Dna Topoisomerase I

Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic.

Rapid and prolonged stalling of human DNA topoisomerase I in UVA-irradiated genomic areas

DNA Repair ◽  
2007 ◽  
Vol 6 (12) ◽  
pp. 1757-1763 ◽  
Author(s):  
Christian Mielke ◽  
Faiza M. Kalfalah ◽  
Morten O. Christensen ◽  
Fritz Boege
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I
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