Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(ii) complex of purpurin: dual poison for human DNA topoisomerase I and II

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59344-59357 ◽  
Author(s):  
Piyal Das ◽  
Chetan Kumar Jain ◽  
Sanjoy K. Dey ◽  
Rajat Saha ◽  
Abhishek Dutta Chowdhury ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Topoisomerase I ◽  
Dna Interaction ◽  
Dna Topoisomerase I ◽  
Oxygen Species ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Anti Tumor Activity ◽  
Human Dna Topoisomerase I

Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic.

scholarly journals Human DNA topoisomerase I-mediated cleavage and recombination of duck hepatitis B virus DNA in vitro

1999 ◽  
Vol 27 (8) ◽  
pp. 1919-1925 ◽  
Author(s):  
P. Pourquier ◽  
Y. Pommier ◽  
A. D. Jensen ◽  
S. S. Gong ◽  
C. E. Rogler
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Duck Hepatitis ◽  
Human Dna ◽  
B Virus ◽  
Human Dna Topoisomerase I

Isodiospyrin as a novel human DNA topoisomerase I inhibitor

2003 ◽  
Vol 66 (10) ◽  
pp. 1981-1991 ◽  
Author(s):  
Chun-Yuan Ting ◽  
Chia-Tse Hsu ◽  
Hsiang-Ting Hsu ◽  
Jin-Shan Su ◽  
Tzong-Yueh Chen ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Rapid and prolonged stalling of human DNA topoisomerase I in UVA-irradiated genomic areas

DNA Repair ◽  
2007 ◽  
Vol 6 (12) ◽  
pp. 1757-1763 ◽  
Author(s):  
Christian Mielke ◽  
Faiza M. Kalfalah ◽  
Morten O. Christensen ◽  
Fritz Boege
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I
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