human dna topoisomerase i
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The human DNA topoisomerase I mutant Gly717Asp: Higher religation rate is not always associated with camptothecin resistance

2019 ◽  
Vol 663 ◽  
pp. 165-172
Author(s):  
Zhenxing Wang ◽  
Ilda D'Annessa ◽  
Cinzia Tesauro ◽  
Alessio Ottaviani ◽  
Bini Chhetri Soren ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I

An Autoantibody Against Human DNA-Topoisomerase I Is a Novel Biomarker for Non-Small Cell Lung Cancer

2018 ◽  
Vol 105 (6) ◽  
pp. 1664-1670 ◽  
Author(s):  
Wen-bin Wu ◽  
Shang-mian Yie ◽  
Shang-rong Ye ◽  
Ke Xie ◽  
Jian-bo Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Topoisomerase I ◽  
Small Cell ◽  
Dna Topoisomerase I ◽  
Small Cell Lung ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Expression of stable and active human DNA topoisomerase I in Pichia pastoris

2018 ◽  
Vol 141 ◽  
pp. 52-62 ◽  
Author(s):  
Mooi Kwai Chan ◽  
Shern Kwok Lim ◽  
Noorizan Miswan ◽  
Ai Lan Chew ◽  
Rahmah Noordin ◽  
...  
Keyword(s):  
Pichia Pastoris ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Design, Synthesis andin vitroAnticancer Activity of a Cu(II) Complex of Carminic Acid: A Novel Small Molecule Inhibitor of Human DNA Topoisomerase I and Topoisomerase II

2016 ◽  
Vol 1 (21) ◽  
pp. 6623-6631 ◽  
Author(s):  
Piyal Das ◽  
Chetan Kumar Jain ◽  
Susanta Roychoudhury ◽  
Hemanta Kumar Majumder ◽  
Saurabh Das
Keyword(s):  
Small Molecule ◽  
Topoisomerase I ◽  
Topoisomerase Ii ◽  
Carminic Acid ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Design Synthesis ◽  
Human Dna ◽  
Molecule Inhibitor ◽  
Human Dna Topoisomerase I

scholarly journals Comparing the expression of human DNA topoisomerase I in KM71H and X33 strains of Pichia pastoris

2016 ◽  
Vol 21 ◽  
pp. 9-17 ◽  
Author(s):  
Ruo Ping Ang ◽  
Leong Sin Teoh ◽  
Mooi Kwai Chan ◽  
Noorizan Miswan ◽  
Boon Yin Khoo
Keyword(s):  
Pichia Pastoris ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations

Nanoscale ◽  
2015 ◽  
Vol 7 (21) ◽  
pp. 9825-9834 ◽  
Author(s):  
Emil L. Kristoffersen ◽  
Line A. Jørgensen ◽  
Oskar Franch ◽  
Michael Etzerodt ◽  
Rikke Frøhlich ◽  
...  
Keyword(s):  
Reaction Kinetics ◽  
Drug Screening ◽  
Optical Sensor ◽  
Topoisomerase I ◽  
Fast Method ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Human DNA topoisomerase I (hTopI) is a nuclear enzyme that catalyzes relaxation of super helical tension that arises in the genome during essential DNA metabolic processes.

scholarly journals Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers

2014 ◽  
Vol 33 (1) ◽  
Author(s):  
Cinzia Tesauro ◽  
Grazia Graziani ◽  
Barbara Arnò ◽  
Laura Zuccaro ◽  
Alessia Muzi ◽  
...  
Keyword(s):  
Binding Sites ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(ii) complex of purpurin: dual poison for human DNA topoisomerase I and II

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59344-59357 ◽  
Author(s):  
Piyal Das ◽  
Chetan Kumar Jain ◽  
Sanjoy K. Dey ◽  
Rajat Saha ◽  
Abhishek Dutta Chowdhury ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Topoisomerase I ◽  
Dna Interaction ◽  
Dna Topoisomerase I ◽  
Oxygen Species ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Anti Tumor Activity ◽  
Human Dna Topoisomerase I

Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic.

Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters

2011 ◽  
Vol 51 (7) ◽  
pp. 1406-1410 ◽  
Author(s):  
René V. Bensasson ◽  
Vincent Zoete ◽  
Akino Jossang ◽  
Bernard Bodo ◽  
Paola B. Arimondo ◽  
...  
Keyword(s):  
Physicochemical Parameters ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I
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