scholarly journals Structural Requirements for RNA Editing in Glutamate Receptor Pre-mRNAs by Recombinant Double-stranded RNA Adenosine Deaminase

1996 ◽  
Vol 271 (21) ◽  
pp. 12221-12226 ◽  
Author(s):  
Stefan Maas ◽  
Thorsten Melcher ◽  
Anne Herb ◽  
Peter H. Seeburg ◽  
Walter Keller ◽  
...  
Keyword(s):  
Adenosine Deaminase ◽  
Rna Editing ◽  
Glutamate Receptor ◽  
Structural Requirements ◽  
Double Stranded Rna

scholarly journals dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing

RNA ◽  
2000 ◽  
Vol 6 (7) ◽  
pp. 1004-1018 ◽  
Author(s):  
MICHAEL J. PALLADINO ◽  
LIAM P. KEEGAN ◽  
MARY A. O'CONNELL ◽  
ROBERT A. REENAN
Keyword(s):  
Adenosine Deaminase ◽  
Rna Editing ◽  
Developmentally Regulated ◽  
Double Stranded Rna

scholarly journals Regulation of glutamate receptor B pre-mRNA splicing by RNA editing

2007 ◽  
Vol 35 (11) ◽  
pp. 3723-3732 ◽  
Author(s):  
Vera K. Schoft ◽  
Sandy Schopoff ◽  
Michael F. Jantsch
Keyword(s):  
Rna Editing ◽  
Glutamate Receptor ◽  
Editing Site ◽  
Mrna Splicing ◽  
Double Stranded Rna ◽  
Glutamate Receptor Subunit ◽  
Splicing Efficiency ◽  
Intron Removal ◽  
Subunit B

Abstract RNA-editing enzymes of the ADAR family convert adenosines to inosines in double-stranded RNA substrates. Frequently, editing sites are defined by base-pairing of the editing site with a complementary intronic region. The glutamate receptor subunit B (GluR-B) pre-mRNA harbors two such exonic editing sites termed Q/R and R/G. Data from ADAR knockout mice and in vitro editing assays suggest an intimate connection between editing and splicing of GluR-B pre-mRNA. By comparing the events at the Q/R and R/G sites, we can show that editing can both stimulate and repress splicing efficiency. The edited nucleotide, but not ADAR binding itself, is sufficient to exert this effect. The presence of an edited nucleotide at the R/G site reduces splicing efficiency of the adjacent intron facilitating alternative splicing events occurring downstream of the R/G site. Lack of editing inhibits splicing at the Q/R site. Editing of both the Q/R nucleotide and an intronic editing hotspot are required to allow efficient splicing. Inefficient intron removal may ensure that only properly edited mRNAs become spliced and exported to the cytoplasm.

A New Mutation of the Double-Stranded RNA-Specific Adenosine Deaminase Gene in a Family with Dyschromatosis Symmetrica Hereditaria

Dermatology ◽  
2006 ◽  
Vol 213 (3) ◽  
pp. 200-203 ◽  
Author(s):  
Yan Liu ◽  
Shengxiang Xiao ◽  
Zhenhui Peng ◽  
Yonglie Chu ◽  
Junmin Wang ◽  
...  
Keyword(s):  
Adenosine Deaminase ◽  
New Mutation ◽  
Double Stranded Rna ◽  
Dyschromatosis Symmetrica Hereditaria
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