scholarly journals From Alcohol Dehydrogenase to a “One-way” Carbonyl Reductase by Active-site Redesign

2010 ◽  
Vol 285 (40) ◽  
pp. 30644-30653 ◽  
Author(s):  
Mario Klimacek ◽  
Bernd Nidetzky
Keyword(s):  
Alcohol Dehydrogenase ◽  
Active Site ◽  
Carbonyl Reductase

scholarly journals Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.

1991 ◽  
Vol 88 (18) ◽  
pp. 8149-8153 ◽  
Author(s):  
T. D. Hurley ◽  
W. F. Bosron ◽  
J. A. Hamilton ◽  
L. M. Amzel
Keyword(s):  
Alcohol Dehydrogenase ◽  
Active Site ◽  
Catalytic Effects

Inhibition of Nicotinoprotein (NAD+-Containing) Alcohol Dehydrogenase bytrans-4-(N,N-Dimethylamino)-Cinnamaldehyde Binding to the Active Site

2003 ◽  
Vol 22 (5) ◽  
pp. 457-461 ◽  
Author(s):  
Sander R. Piersma ◽  
Annika Norin ◽  
Simon de Vries ◽  
Hans Jörnvall ◽  
Johannis A. Duine
Keyword(s):  
Alcohol Dehydrogenase ◽  
Active Site

Mapping of the active site of alcohol dehydrogenase with low-molecular ligands

2000 ◽  
Vol 26 (3) ◽  
pp. 157-163
Author(s):  
A. S. Kutsenko ◽  
D. A. Kuznetsov ◽  
V. V. Poroikov ◽  
V. G. Tumanyan
Keyword(s):  
Alcohol Dehydrogenase ◽  
Active Site

scholarly journals The structure of the quinoprotein alcohol dehydrogenase of Acetobacter aceti modelled on that of methanol dehydrogenase from Methylobacterium extorquens

1995 ◽  
Vol 308 (2) ◽  
pp. 375-379 ◽  
Author(s):  
G E Cozier ◽  
I G Giles ◽  
C Anthony
Keyword(s):  
Alcohol Dehydrogenase ◽  
Active Site ◽  
Mechanisms Of Action ◽  
Methanol Dehydrogenase ◽  
Model Structure ◽  
Methylobacterium Extorquens ◽  
Acetobacter Aceti ◽  
Active Site Region

The 1.94 A structure of methanol dehydrogenase has been used to provide a model structure for part of a membrane quinohaemoprotein alcohol dehydrogenase. The basic superbarrel structure and the active-site region are retained, indicating essentially similar mechanisms of action, but there are considerable differences in the external loops, particularly those involved in formation of the shallow funnel leading to the active site.

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