Mobilisation of intracellular calcium by P2Y2 receptors in cultured, non-transformed bovine ciliary epithelial cells

1997 ◽  
Vol 16 (10) ◽  
pp. 1006-1016 ◽  
Author(s):  
Mohammad Shahidullah ◽  
William S. Wilson
Keyword(s):  
Epithelial Cells ◽  
Intracellular Calcium ◽  
P2y2 Receptors

scholarly journals An Intracellular Calcium Signal Activates p70 but Not p90 Ribosomal S6 Kinase in Liver Epithelial Cells

1997 ◽  
Vol 272 (3) ◽  
pp. 1920-1928 ◽  
Author(s):  
Lee M. Graves ◽  
Yaqin He ◽  
John Lambert ◽  
Deborah Hunter ◽  
Xiong Li ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intracellular Calcium ◽  
Calcium Signal ◽  
S6 Kinase ◽  
Liver Epithelial Cells ◽  
P90 Ribosomal S6 Kinase ◽  
Ribosomal S6 Kinase

scholarly journals Mechanosensitive calcium signaling promotes epithelial tight junction remodeling by activating RhoA

2021 ◽  
Author(s):  
Saranyaraajan Varadarajan ◽  
Rachel E. Stephenson ◽  
Eileen R. Misterovich ◽  
Jessica L. Wu ◽  
Ivan S. Erofeev ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intracellular Calcium ◽  
Tight Junctions ◽  
Calcium Influx ◽  
Cell Junctions ◽  
Mechanical Stimuli ◽  
Local Repair ◽  
Transient Activation ◽  
Epithelial Tight Junction ◽  
Sense And Respond

Epithelia maintain an effective barrier by remodeling cell-cell junctions in response to mechanical stimuli. Cells often respond to mechanical stress through activating RhoA and remodeling actomyosin. Previously, we found that local leaks in the barrier are rapidly repaired by localized, transient activation of RhoA – ″Rho flares″ – but how Rho flares are initiated remains unknown. Here, we discovered that intracellular calcium flashes occur in Xenopus laevis epithelial cells undergoing Rho flare-mediated remodeling of tight junctions. Calcium flashes originate at the site of barrier leaks and propagate into the cell. Depletion of intracellular calcium or inhibition of mechanosensitive calcium channels (MSC) reduced the amplitude of calcium flashes and diminished the activation of Rho flares. Furthermore, MSC-dependent calcium influx was necessary to maintain global barrier function by regulating local repair of tight junctions through efficient junction contraction. We propose that MSC-dependent calcium flashes are an important mechanism allowing epithelial cells to sense and respond to local leaks induced by mechanical stimuli.

Erythromycin Inhibits ATP-Induced Intracellular Calcium Responses in Bovine Tracheal Epithelial Cells

1998 ◽  
Vol 19 (5) ◽  
pp. 799-804 ◽  
Author(s):  
Mitsuko Kondo ◽  
Soichiro Kanoh ◽  
Jun Tamaoki ◽  
Hideki Shirakawa ◽  
Shunichi Miyazaki ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intracellular Calcium ◽  
Tracheal Epithelial Cells ◽  
Tracheal Epithelial

scholarly journals Modulation of P2Y2 receptors in bovine cumulus oocyte complexes: effects on intracellular calcium, zona hardening and developmental competence

2020 ◽  
Vol 16 (1) ◽  
pp. 85-96
Author(s):  
E. Fonseca ◽  
P. Mesquita ◽  
C. C. Marques ◽  
M. C. Baptista ◽  
J. Pimenta ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Developmental Competence ◽  
P2y2 Receptors ◽  
Zona Hardening
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