scholarly journals The evolutionary history of HSA7/16 synteny in vertebrates: a critical interpretation of comparative cytogenetic and genome sequence data

Caryologia ◽  
2013 ◽  
Vol 66 (3) ◽  
pp. 236-242
Author(s):  
Barbara Picone ◽  
Luca Sineo
Science ◽  
2018 ◽  
Vol 360 (6392) ◽  
pp. 1028-1032 ◽  
Author(s):  
S. Sunna Ebenesersdóttir ◽  
Marcela Sandoval-Velasco ◽  
Ellen D. Gunnarsdóttir ◽  
Anuradha Jagadeesan ◽  
Valdís B. Guðmundsdóttir ◽  
...  

Opportunities to directly study the founding of a human population and its subsequent evolutionary history are rare. Using genome sequence data from 27 ancient Icelanders, we demonstrate that they are a combination of Norse, Gaelic, and admixed individuals. We further show that these ancient Icelanders are markedly more similar to their source populations in Scandinavia and the British-Irish Isles than to contemporary Icelanders, who have been shaped by 1100 years of extensive genetic drift. Finally, we report evidence of unequal contributions from the ancient founders to the contemporary Icelandic gene pool. These results provide detailed insights into the making of a human population that has proven extraordinarily useful for the discovery of genotype-phenotype associations.


2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Shaohua Fan ◽  
Derek E. Kelly ◽  
Marcia H. Beltrame ◽  
Matthew E. B. Hansen ◽  
Swapan Mallick ◽  
...  

Author(s):  
Amnon Koren ◽  
Dashiell J Massey ◽  
Alexa N Bracci

Abstract Motivation Genomic DNA replicates according to a reproducible spatiotemporal program, with some loci replicating early in S phase while others replicate late. Despite being a central cellular process, DNA replication timing studies have been limited in scale due to technical challenges. Results We present TIGER (Timing Inferred from Genome Replication), a computational approach for extracting DNA replication timing information from whole genome sequence data obtained from proliferating cell samples. The presence of replicating cells in a biological specimen leads to non-uniform representation of genomic DNA that depends on the timing of replication of different genomic loci. Replication dynamics can hence be observed in genome sequence data by analyzing DNA copy number along chromosomes while accounting for other sources of sequence coverage variation. TIGER is applicable to any species with a contiguous genome assembly and rivals the quality of experimental measurements of DNA replication timing. It provides a straightforward approach for measuring replication timing and can readily be applied at scale. Availability and Implementation TIGER is available at https://github.com/TheKorenLab/TIGER. Supplementary information Supplementary data are available at Bioinformatics online


Data in Brief ◽  
2021 ◽  
Vol 35 ◽  
pp. 106784
Author(s):  
Chinda Chhe ◽  
Ayaka Uke ◽  
Sirilak Baramee ◽  
Umbhorn Ungkulpasvich ◽  
Chakrit Tachaapaikoon ◽  
...  

Data in Brief ◽  
2020 ◽  
Vol 33 ◽  
pp. 106416
Author(s):  
Asset Daniyarov ◽  
Askhat Molkenov ◽  
Saule Rakhimova ◽  
Ainur Akhmetova ◽  
Zhannur Nurkina ◽  
...  

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Lynsey K. Whitacre ◽  
Jesse L. Hoff ◽  
Robert D. Schnabel ◽  
Sara Albarella ◽  
Francesca Ciotola ◽  
...  

Data in Brief ◽  
2021 ◽  
Vol 34 ◽  
pp. 106640
Author(s):  
Pankaj Kumar Arora ◽  
Rupali Mishra ◽  
Rishabh Anand Omar ◽  
Raj Shekhar Saroj ◽  
Alok Srivastava ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document