A Convenient Preparation of Carboxy-γ-pyrone Derivatives: Meconic Acid and Comenic Acid

In a paper on Comenic Acid, read before this Society in April of last year, and since honoured with a place in its Transactions, I mentioned my being engaged in an investigation on Meconic Acid; the details of the experiments referred to form the matter of the present communication.My object in undertaking this subject was to ascertain if products corresponding to those described as derived from comenic acid were formed under similar circumstances in the case of meconic acid. I also thought it probable, that as the former is itself a derivative of the latter, the changes undergone by meconic acid in some reactions, would be found to result in substances apparently the immediate derivatives of comenic acid. This remark refers to the action of heat on meconate of ammonia; and it will be seen that the expectation was realised. A similar result was found in other instances, where it had not been anticipated.

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3. On Comenic Acid

Proceedings of the Royal Society of Edinburgh ◽

10.1017/s0370164600047337 ◽

1882 ◽

Vol 11 ◽

pp. 241-245

Author(s):

D. B. Dott

Keyword(s):

Hydrochloric Acid ◽

Ammonium Salt ◽

Boiling Water ◽

Short Paper ◽

Comenic Acid ◽

Aqueous Hydrochloric Acid ◽

Meconic Acid

In continuation of a short paper on meconic acid previously communicated to the Society, I submit the following notice of some of the salts of comenic acid.As is well known, comenic acid is formed from meconic acid by elimination of carbonic anhydride, according to the equation -C7H4O7=C6H4O5+CO2. This change may be effected by heat alone, but a better product is obtained by the action of boiling aqueous hydrochloric acid. It was by the latter method that the acid used in my experiments was prepared. Comenic acid is easily purified by crystallisation from boiling water, in which it is sparingly soluble, and by conversion into ammonium salt, which is likewise purified by recrystallisation. Comenate of ammonia forms long well-defined prisms, which are much less soluble in water than the corresponding salt of meconic acid.

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The effect of boric acid on the solubility in water and on the Conductivity of Some y-pyrone Carboxylic acids; some data concerning meconic acid, comenic acid and chelidonic acid

Recueil des Travaux Chimiques des Pays-Bas ◽

10.1002/recl.19240431207 ◽

2010 ◽

Vol 43 (12) ◽

pp. 879-893 ◽

Cited By ~ 7

Author(s):

P. E. Verkade

Keyword(s):

Boric Acid ◽

Carboxylic Acids ◽

Solubility In Water ◽

Comenic Acid ◽

Meconic Acid

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2. On Meconic Acid, and some of its Derivatives.

Proceedings of the Royal Society of Edinburgh ◽

10.1017/s0370164600027334 ◽

1857 ◽

Vol 3 ◽

pp. 99-101

Author(s):

Henry How

Keyword(s):

Comenic Acid ◽

Meconic Acid

The author commenced his paper by observing that it formed a sequel to one communicated to the Society last Session on comenic acid; his object in the present instance having been partly to ascertain whether some of the substances described in his former paper could not be derived from meconic acid, which is the parent acid of comenic acid. This he shewed to be the case; but before detailing these experiments, he gave his process for purifying meconic acid, which is that of Gregory, modified by the use of ammonia instead of potass.

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