Pseudo High-Throughput Development and Optimization of the Electrochemical Oxidation of Sensitive Propargylic Benzylic Alco-hols

The electrochemical oxidation of sensitive propargylic benzylic alcohols having varying substituents is reported. The ther-mal oxidation of propargylic benzylic alcohols presents an acute challenge in the synthesis of complex molecules and various traditional oxidation methods proceed with low efficiency or not at all. We describe the convenient preparation and charac-terization of N-hydroxytetrafluorophthalimide (TFNHPI) and a practical, green electrochemical oxidation protocol that em-ploys TFNHPI as a stable, efficient electrochemical mediator. The electrochemical method employing TFNHPI to oxidize propargylic benzylic alcohols was developed and optimized in pseudo high-throughput fashion using a bank of inexpensive two-electrode power supplies. The electrochemical oxidation of propargylic benzylic alcohol was also leveraged to develop efficient synthetic pathways to prepare gram quantities of resveratrol natural products such as the pauciflorols.

Convenient Preparation and Spectroscopic Characterization of 7R-Hydroxymatairesinol

The preparation of 7R-HMR (allo-hydroxymatairesinol) is reported by: (a) NaBH4 kinetic reduction of 7R/7S diastereomeric mixture; and (b) epimerization of the C7 hydroxyl group by Mitsunobu reaction and subsequent ester hydrolysis. The availability of highly pure target compound (7R-HMR) made it possible to confirm the structure of the target compound and to complete the full spectroscopic characterization.

A Review of 99mTc-labeled Tumor Metabolic Imaging Agents

: In recent years, with the development of nuclear medicine imaging technology, radionuclide-labeled tumor imaging agents have shown unique advantages in the early diagnosis of tumors. Due to the relatively low cost of SPECT in the clinic with the convenient preparation and suitable properties of 99mTc, 99mTc-labeled tumor metabolic imaging agents prepared based on principles of tumor metabolism have attracted considerable attention. This article briefly introduces the progress in the research of 99mTc-labeled glucose derivatives, amino acid derivatives, nucleotide derivatives and other tumor metabolic imaging agents and proposes the prospects for the development of 99mTc-labeled tumor metabolic imaging agents.

Using a reactive emulsifier to construct simple and convenient nanocapsules loaded with lambda-cyhalothrin to achieve efficient foliar delivery and insecticidal synergies

Nanocapsules are a promising controlled release formulation for foliar pest control. However, the complicated process and high cost limit widespread use in agriculture, so a simpler and more convenient preparation...