scholarly journals XXV.—On Meconic Acid, and some of its Derivatives

1853 ◽  
Vol 20 (3) ◽  
pp. 401-416
Author(s):  
Henry How
Keyword(s):  
Present Communication ◽  
Comenic Acid ◽  
Derivatives Of ◽  
Meconic Acid

In a paper on Comenic Acid, read before this Society in April of last year, and since honoured with a place in its Transactions, I mentioned my being engaged in an investigation on Meconic Acid; the details of the experiments referred to form the matter of the present communication.My object in undertaking this subject was to ascertain if products corresponding to those described as derived from comenic acid were formed under similar circumstances in the case of meconic acid. I also thought it probable, that as the former is itself a derivative of the latter, the changes undergone by meconic acid in some reactions, would be found to result in substances apparently the immediate derivatives of comenic acid. This remark refers to the action of heat on meconate of ammonia; and it will be seen that the expectation was realised. A similar result was found in other instances, where it had not been anticipated.

Quinazolinone Derivatives of Biological Interest V. Novel 4(3H)-Quinazolinones with Sedative-Hypnotic, Anticonvulsant and Antiinflammatory Activities

1993 ◽  
Vol 58 (8) ◽  
pp. 1963-1968 ◽  
Author(s):  
Abdel-Alim M. Abdel-Alim ◽  
Abdel-Nasser A. El-Shorbagi ◽  
Mahmoud A. El-Gendy ◽  
Hosny A. H. El-Shareif
Keyword(s):  
Present Communication ◽  
Biological Interest ◽  
Quinazoline Derivatives ◽  
Quinazolinone Derivatives ◽  
Derivatives Of

2-Methyl-4(3H)-quinazolines carrying alkyl, cycloalkyl, aralkyl or aryl substituents at N-3 of the quinazoline ring exhibit analgetic, antipyretic and antiinflammatory activities comparable to those of aspirin and phenylbutazone. In our previous work, various 4(3H)-quinazoline derivatives were prepared. The present communication is a continuation of our effort in this field.

scholarly journals The antiseptic and trypanocidal action of certain styryl and anil benzthiazole derivatives

1931 ◽  
Vol 108 (755) ◽  
pp. 119-129 ◽  
Keyword(s):  
Pyridine Ring ◽  
Membered Ring ◽  
Present Series ◽  
Quinoline Derivatives ◽  
Present Communication ◽  
Quinoline Series ◽  
Derivatives Of

In view of the powerful antiseptic action of certain anil quinoline compounds (Browning, Cohen, Ellingworth and Gulbransen, 1926) and the trypanocidal action of these and especially of some styryl quinoline derivatives (Browning, Cohen, Ellingworth and Gulbransen, 1929), it was thought desirable to examine the action of similar compounds containing other heterocyclic nuclei. The present communication is concerned with a number of derivatives of benzthiazole, in which the pyridine ring of the quinoline group is replaced by a five-membered ring containing both nitrogen and sulphur. Antiseptic Action . Antiseptic power was estimated as in previous communications (Browning, Cohen, Elingworth and Gulbransen, 1926, 1928). Throughout the range of the anil benzthiazole compounds examined the antiseptic activity is considerably lower than that of the corresponding quinoline compounds. The styryl compounds tend also to be weak in their antiseptic action and in this respect resemble the styryl quinoline series, but in general they are not inferior to the latter in potency. Frequently in the present series of compounds the irregularities in action, previously commented upon, were observed in marked degree.

scholarly journals Synthesis and Biological Activity of Novel Comenic Acid Derivatives Containing Isoxazole and Isothiazole Moieties

2018 ◽  
Vol 13 (11) ◽  
pp. 1934578X1801301 ◽  
Author(s):  
Alexey V. Kletskov ◽  
Vladimir I. Potkin ◽  
Irina A. Kolesnik ◽  
Sergey K. Petkevich ◽  
Anastasia V. Kvachonak ◽  
...  
Keyword(s):  
Biological Activity ◽  
Brain Tumors ◽  
Synergetic Effect ◽  
Antitumor Drug ◽  
Water Soluble ◽  
First Line ◽  
Comenic Acid ◽  
Acidic Catalysis ◽  
Derivatives Of

Methyl 5-hydroxy-4-oxo-4 H-pyran-2-carboxylate was synthesized by esterification of methanol with comenic acid under acidic catalysis. The obtained ester was alkylated with 3-(chloromethyl)-5-phenylisoxazole and 4,5-dichloro-3-(chloromethyl)isothiazole to afford corresponding conjugates containing isoxazole and isothiazole moieties which then were transformed into water-soluble Li-salts. During the bioassays of synthesized isoxazole and isothiazole derivatives of comenic acid in mixtures with first-line antitumor drug Temobel (Temozolomid) used in brain tumors chemotherapy, a synergetic effect was observed.

scholarly journals V. Contributions to the chemistry of chlorophyll. No. V

1894 ◽  
Vol 55 (331-335) ◽  
pp. 351-356 ◽  
Keyword(s):  
Present Communication ◽  
Considerable Difficulty ◽  
Derivatives Of

My previous papers were devoted to a description of various products derived from chlorophyll and their qualitative reactions. In the present communication I propose to give an account of some experiments made with a view to ascertain the composition of some of the derivatives of chlorophyll previously described. Considerable difficulty was experienced in obtaining quantities of the various substances in a state sufficiently pure for analysis.

scholarly journals The trypanocidal action of some derivatives of anil and styryl quinoline

1929 ◽  
Vol 105 (735) ◽  
pp. 99-111 ◽  
Keyword(s):  
Therapeutic Agents ◽  
Therapeutic Action ◽  
Present Communication ◽  
Similar Treatment ◽  
Loss Of Weight ◽  
Experimentelle Therapie ◽  
Therapeutic Results ◽  
The Subject ◽  
High Degree ◽  
Derivatives Of

The powerful antiseptic action of certain basic derivatives of anil and styryl quinoline formed the subject of previous communications. The present communication is concerned with the action of a number of these substances on trypanosome infections. They constitute new types of trypanocidal agents, and in the case of certain members of the styryl series a high degree of effectiveness is attained. Biological Section . Method of Testing Therapeutic Action.—Mice infected with T. brucei were used for this purpose. They were inoculated with a suspension in saline of the blood of an infected mouse containing abundant parasites. The course of the infection was regular; on the day following inoculation the blood showed scanty trypanosomes which increased in numbers progressively, and death of the animal occurred as a rule about 72 hours was observed only very rarely. In the course of the investigation three strains of T. brucei were used, viz., Prowazek's strain obtained from the Institut für Experimentelle Therapie, Frankfurt a. Main, and two strains furnished at different times by Prof. Mesnil, Institut Pasteur, Paris, and designated Ehrlich's ferox . Care was taken to ascertain, as far as possible, by the use of standard therapeutic agents, such as arsacetin tryparosan, trypaflavin, trypanblue, and Bayer 205, that the therapeutic, results obtained with the respective strains were closely similar. Treatment was as a rule instituted on the day following inoculation, when scanty parasites were present in the blood, and consisted of a subcutaneous injection of the concentration stated in the table, in the proportion of 1 c. c. per 20 grams of body weight. To begin with a dose was chosen which approximated to the largest amount borne in uninfected animals without producing toxic effects, e. g ., loss of weight, and when only one dose is shown in the table it is this which is indicated. The blood was then examined daily for a month and at intervals afterwards for at lease 2 to 3 months before cure was recorded. The most effective substance were also tested in the chronic trypanosomiasis produced by T. brucei in rabbits.

3. On Comenic Acid

1882 ◽  
Vol 11 ◽  
pp. 241-245
Author(s):  
D. B. Dott
Keyword(s):  
Hydrochloric Acid ◽  
Ammonium Salt ◽  
Boiling Water ◽  
Short Paper ◽  
Comenic Acid ◽  
Aqueous Hydrochloric Acid ◽  
Meconic Acid

In continuation of a short paper on meconic acid previously communicated to the Society, I submit the following notice of some of the salts of comenic acid.As is well known, comenic acid is formed from meconic acid by elimination of carbonic anhydride, according to the equation -C7H4O7=C6H4O5+CO2. This change may be effected by heat alone, but a better product is obtained by the action of boiling aqueous hydrochloric acid. It was by the latter method that the acid used in my experiments was prepared. Comenic acid is easily purified by crystallisation from boiling water, in which it is sparingly soluble, and by conversion into ammonium salt, which is likewise purified by recrystallisation. Comenate of ammonia forms long well-defined prisms, which are much less soluble in water than the corresponding salt of meconic acid.

scholarly journals Antiseptic compounds: some further derivatives of anilquinoline

1928 ◽  
Vol 103 (725) ◽  
pp. 404-411 ◽  
Keyword(s):  
General Type ◽  
Present Communication ◽  
Derivatives Of

It was shown in a former paper ('Roy. Soc. Proc.,' B, vol. 96, p. 317) that a number of derivatives of amino anilquinoline acted as powerful antiseptics, being especially potent against B. coli . The present communication forms a continuation of this work, and describes further compounds of the same general type. Antiseptic power was estimated as described in the previous paper ( loc. cit. ). The results there recorded pointed to a tendency towards increased antiseptic action as the mass of the molecule was augmented, provided that the "alternate linkage system" was preserved intact.

A Convenient Preparation of Carboxy-γ-pyrone Derivatives: Meconic Acid and Comenic Acid

2018 ◽  
Vol 50 (5) ◽  
pp. 512-516 ◽  
Author(s):  
Paul Güntzel ◽  
Leonard Forster ◽  
Curd Schollmayer ◽  
Ulrike Holzgrabe
Keyword(s):  
Comenic Acid ◽  
Convenient Preparation ◽  
Meconic Acid

2. On Meconic Acid, and some of its Derivatives.

1857 ◽  
Vol 3 ◽  
pp. 99-101
Author(s):  
Henry How
Keyword(s):  
Comenic Acid ◽  
Meconic Acid

The author commenced his paper by observing that it formed a sequel to one communicated to the Society last Session on comenic acid; his object in the present instance having been partly to ascertain whether some of the substances described in his former paper could not be derived from meconic acid, which is the parent acid of comenic acid. This he shewed to be the case; but before detailing these experiments, he gave his process for purifying meconic acid, which is that of Gregory, modified by the use of ammonia instead of potass.

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