Stability - Indicating Method For The Determination of Bromazepam And Delorazepam Via Proton Magnetic Resonance Spectroscopy

1997 ◽  
Vol 30 (5) ◽  
pp. 915-932 ◽  
Author(s):  
S. Z. El-Khateeb ◽  
S. M. Amer ◽  
S. A. Abdel-Razek ◽  
M. M. Amer
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Stability Indicating ◽  
Stability Indicating Method

Determination of Enantiomeric Purity of Tranylcypromine Sulfate by Proton Magnetic Resonance Spectroscopy with Chiral Lanthanide Shift Reagent

1989 ◽  
Vol 72 (4) ◽  
pp. 552-555
Author(s):  
George M Hanna ◽  
Cesar A Lau-Cam
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Optical Purity ◽  
Enantiomeric Purity ◽  
Molar Ratio ◽  
Resonance Spectroscopy ◽  
Lanthanide Chelate

Abstract Optimum experimental conditions were developed for determination of the optical purity of samples of tranylcypromine sulfate by proton magnetic resonance spectroscopy after complexation with the chiral lanthanide chelate Eu(hfc).3. At a substrate concentration of 0.25M (0.125M as sulfate) in CDC13 and an Eu(hfc)3 to substrate molar ratio of 1, the methine proton geminal to the amino group in the cyclopropane ring showed the largest induced shift and largest enantiomeric induced shift difference. From the relative intensities of the resolved (+)-CH-NH2 protons (15.77 ppm) and (-)-CH-NH2 proton (16.04 ppm), the enantiomeric purity and percentage compositions were readily calculated. The mean ± SD recovery of (+)- tranylcypromine sulfate from synthetic enantiomeric mixtures was 101.02 ± 2.59 (n = 6).

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