Hantzsch-like synthesis of the 10b-azachrysenes, spirocyclic oxindole of 10b-azachrysene and 10a-azaphenanthrene utilizing 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile as a precursor

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A highly stereoselective sequential vinylogous aldol reaction/transesterification of methyl-substituted olefinic butyrolactones and isatins was developed with 10 mol% Takemoto's amine–thiourea catalyst.


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