Late-Onset Leber’s Hereditary Optic Neuropathy with Concurrent Retinal Detachment and Retrobulbar Visual Pathway Involvement

2021 ◽  
pp. 1-6
Author(s):  
Xiaojun Zhang ◽  
Sean Meagher ◽  
Min Kyu Han ◽  
Jorge Kattah
Keyword(s):  
Retinal Detachment ◽  
Optic Neuropathy ◽  
Late Onset ◽  
Visual Pathway ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Hereditary Optic Neuropathy

scholarly journals Late onset of Leber's hereditary optic neuropathy in HIV infection

1999 ◽  
Vol 83 (10) ◽  
pp. 1194k-1194k ◽  
Author(s):  
C. LUKE ◽  
O. A CORNELY ◽  
J. FRICKE ◽  
E. LEHRER ◽  
K. U. BARTZ-SCHMIDT ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Optic Neuropathy ◽  
Late Onset ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Hereditary Optic Neuropathy

scholarly journals Late-onset Leber’s hereditary optic neuropathy: the role of environmental factors in hereditary diseases

2019 ◽  
Vol 12 (3) ◽  
pp. e227977
Author(s):  
Nuno Moura-Coelho ◽  
Rita Pinto Proença ◽  
Joana Tavares Ferreira ◽  
João Paulo Cunha
Keyword(s):  
Environmental Factors ◽  
Optic Neuropathy ◽  
Late Onset ◽  
Young Male ◽  
Hereditary Diseases ◽  
Incomplete Penetrance ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Hereditary Optic Neuropathy

Leber’s hereditary optic neuropathy (LHON) is an optic neuropathy of mitochondrial inheritance, characterised by incomplete penetrance and variable expressivity. Typically, young male patients present with sequential, severe, rapidly progressive loss of central vision, with characteristic funduscopic findings. However, LHON may present at any age, in both genders, and fundus examination may be normal. Evidence has emerged to support the role of environmental factors in triggering LHON, by disrupting the normal mechanisms of mitochondrial function. We present two clinical cases of LHON of late onset, and provide a literature review on atypical cases of LHON and the role of environmental triggers.

scholarly journals Late onset of Leber's hereditary optic neuropathy precipitated by anaemia

Eye ◽  
2004 ◽  
Vol 18 (10) ◽  
pp. 1017-1018 ◽  
Author(s):  
S Goyal ◽  
P Riordan-Eva ◽  
R L Coakes
Keyword(s):  
Optic Neuropathy ◽  
Late Onset ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Hereditary Optic Neuropathy

Late onset Leber's Hereditary Optic Neuropathy

2008 ◽  
Vol 32 (1) ◽  
pp. 41-42 ◽  
Author(s):  
Alexander Demidenko ◽  
Roya Vakili ◽  
Eric R. Eggenberger ◽  
David I. Kaufman
Keyword(s):  
Optic Neuropathy ◽  
Late Onset ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Hereditary Optic Neuropathy
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