The role of endoscopic biopsy and third ventriculostomy in the management of pineal region tumours

2001 ◽  
Vol 15 (4) ◽  
pp. 305-311 ◽  
Author(s):  
I. K. Pople, T. C. Athanasiou, D. R. S
Keyword(s):  
Pineal Region ◽  
Endoscopic Biopsy ◽  
Third Ventriculostomy ◽  
Pineal Region Tumours

Endoscopic biopsy during third ventriculostomy in paediatric pineal region tumours

2008 ◽  
Vol 24 (11) ◽  
pp. 1323-1326 ◽  
Author(s):  
Yahia Z. Al-Tamimi ◽  
Deepti Bhargava ◽  
Surash Surash ◽  
Roberto E. Ramirez ◽  
Federica Novegno ◽  
...  
Keyword(s):  
Pineal Region ◽  
Endoscopic Biopsy ◽  
Third Ventriculostomy ◽  
Pineal Region Tumours

scholarly journals The Role of Neuroendoscopy in the Treatment of Pineal Region Tumors

2018 ◽  
Vol 22 (2) ◽  
pp. 21-25
Author(s):  
Flávio Ramalho Romero ◽  
Eduardo De Freitas Bertolini ◽  
Adalberto Sestari ◽  
Sérgio Soares Guerrero ◽  
Ramon Barbalha Guerrero ◽  
...  
Keyword(s):  
Diagnostic Yield ◽  
Pineal Region ◽  
Endoscopic Biopsy ◽  
Third Ventriculostomy ◽  
Tumor Biopsy ◽  
Pineal Tumors ◽  
Pineal Region Tumors ◽  
Therapeutic Outcomes ◽  
Initial Procedure

Object. The authors report their experience in six patients presenting with pineal tumors and associated hydrocephalus who underwent an endoscopic biopsy procedure and third ventriculostomy (ETV) in a single setting. The purpose of this report is to discuss the role of neuroendoscopic procedures in the management of pineal region tumors. Methods. A retrospective review of patients undergoing simultaneous ETV and tumor biopsy was ndertaken. Neuroendoscopic surgery was first applied for tumor debulking with tissue diagnosis and gross morphological analysis of the tumor and the intraventricular structures, followed by third ventriculostomy. Subsequent procedures were determined on the basis of verified individual tumors. Results. Over a 2-year interval, 6 patients underwent simultaneous ETV and tumor management. These patients ranged from 6 to 54 years of age (mean 24.3 years). All cases were completed without complications or the need for an additional CSF diversionary procedure within 6 months. The diagnostic yield of the biopsy was 100%. Favorable therapeutic outcomes were obtained in all cases of germinoma and pineoblastoma, with follow-up periods ranging from 6 to 24 months. Conclusion. The majority of our patients with dilated ventricles were treated satisfactorily with effective neuroendoscopic procedures as the initial procedure, avoiding unnecessary craniotomy and promising excellent therapeutic outcomes.

Endoscopic Biopsy and Third Ventriculostomy for the Management of Pineal Region Tumors

2015 ◽  
Vol 83 (4) ◽  
pp. 543-547 ◽  
Author(s):  
Aminul I. Ahmed ◽  
Malik J. Zaben ◽  
Nijaguna V. Mathad ◽  
Owen C.E. Sparrow
Keyword(s):  
Pineal Region ◽  
Endoscopic Biopsy ◽  
Third Ventriculostomy ◽  
Pineal Region Tumors

Subarachnoid dissemination of intraventricular tumors following simultaneous endoscopic biopsy and third ventriculostomy

2010 ◽  
Vol 5 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Neal Luther ◽  
William R. Stetler ◽  
Ira J. Dunkel ◽  
Paul J. Christos ◽  
John C. Wellons ◽  
...  
Keyword(s):  
High Risk ◽  
Mr Imaging ◽  
Third Ventricle ◽  
Tumor Resection ◽  
Pineal Region ◽  
Endoscopic Biopsy ◽  
Third Ventriculostomy ◽  
Leptomeningeal Disease ◽  
Leptomeningeal Dissemination ◽  
Subarachnoid Dissemination

Object Endoscopic biopsy with concomitant third ventriculostomy (ETV) is a well-established diagnostic and therapeutic maneuver in patients presenting with noncommunicating hydrocephalus resulting from a tumor of the pineal region or posterior third ventricle. Fenestration of the floor of the third ventricle theoretically provides a conduit for the subarachnoid dissemination of an intraventricular tumor. The aim of this study was to ascertain the rate of leptomeningeal dissemination following this surgical procedure. Methods The authors conducted a review of all patients for whom an ETV and simultaneous endoscopic biopsy procedure or tumor resection had been performed at their institutions between 1995 and 2008. Patients were divided into high or low risk groups by leptomeningeal metastatic potential based on pathology. All available postoperative clinical and radiographic data, including MR imaging of the brain and spinal cord, as well as CSF sampling were evaluated when available. A review of the literature was then conducted to establish rates of distant leptomeningeal dissemination for comparative purposes. Results Thirty-two patients satisfied the criteria for study inclusion. Pathology revealed that 22 had a high risk for leptomeningeal dissemination. New leptomeningeal disease (1 yolk sac tumor and 1 pineoblastoma) occurred in 2 patients. The median clinical and brain MR imaging follow-ups overall were 34 (range 2–103 months) and 38 months (range 1–94 months), respectively. Follow-up MR imaging of the spine was performed in 12 patients (median 7 months postoperation), and CSF was analyzed in 15 patients (median 1 month postoperation). A Kaplan-Meier survival analysis predicted a 2-year metastasis-free survival of 94.7% for high-risk patients. Baseline rates of dissemination when ETV was not performed were in general between 8 and 24% for various high-risk pathologies according to a literature review. Conclusions The rate of leptomeningeal metastasis of tumors in this biopsy and ETV study was not increased when compared with rates from large series in the literature.

Role of radiosurgery in the management of pineal region tumours: indications, method, outcome

2015 ◽  
Vol 61 (2-3) ◽  
pp. 216-222 ◽  
Author(s):  
A. Balossier ◽  
S. Blond ◽  
G. Touzet ◽  
T. Sarrazin ◽  
E. Lartigau ◽  
...  
Keyword(s):  
Pineal Region ◽  
Pineal Region Tumours

Endoscopic biopsy of brain tumors in children: diagnostic success and utility in guiding treatment strategies

2010 ◽  
Vol 5 (3) ◽  
pp. 255-262 ◽  
Author(s):  
Edward S. Ahn ◽  
Liliana Goumnerova
Keyword(s):  
Brain Tumors ◽  
Tumor Marker ◽  
Lateral Ventricle ◽  
Endoscopic Third Ventriculostomy ◽  
Obstructive Hydrocephalus ◽  
Pineal Region ◽  
Endoscopic Biopsy ◽  
Neurological Deficits ◽  
Third Ventriculostomy ◽  
Consecutive Series

Object Endoscopic biopsy is an important minimally invasive method of diagnosis in the initial management of lesions in children with intraventricular and periventricular tumors. The procedure can be performed in conjunction with CSF-diverting procedures for obstructive hydrocephalus. The authors present their single-institution experience in a predominantly pediatric series with respect to diagnostic efficacy, utility in guiding treatment plans, and safety. Methods A retrospective review was conducted in a consecutive series of patients who underwent endoscopic biopsy of brain tumors during a 13-year period. Results There were 33 endoscopic biopsies in 31 patients (16 males and 15 females). The average age of the patients was 11.3 years, with a mean follow-up duration of 2.4 years. The majority of biopsies were performed in conjunction with CSF-diverting procedures, such as endoscopic third ventriculostomy or fenestration of the septum pellucidum. Overall, 23 (70%) of 33 biopsies were diagnostic, with results that directed subsequent treatment. When stratified by tumor location, biopsy samples obtained in the lateral ventricle or pineal region were more favorable toward a successful diagnosis than those in the thalamus or tectal region. In 4 cases, elevated CSF tumor marker levels led to modification of the diagnosis and appropriate adjustment of treatment. The endoscopic third ventriculostomy success rate was 82.4%. There were 2 major complications (6.1%), which resulted in neurological deficits. There were no procedure-related deaths. Conclusions Endoscopic biopsy is an effective means of diagnosis of brain tumors in children. The diagnostic power may be more favorable with tumors in the lateral ventricle or pineal region. Collection of CSF during the procedure for tumor marker analysis is an integral component of diagnosis.

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