Estimated Generalized Estimating Equation for Correlated Failure Time Data with Auxiliary Covariates

2011 ◽  
Vol 40 (22) ◽  
pp. 4086-4103
Author(s):  
Yanyan Liu ◽  
Zhongshang Yuan
2011 ◽  
Vol 18 (1) ◽  
pp. 116-138
Author(s):  
Yanyan Liu ◽  
Zhongshang Yuan ◽  
Jianwen Cai ◽  
Haibo Zhou

2021 ◽  
pp. 096228022110616
Author(s):  
Mengzhu Yu ◽  
Yanqin Feng ◽  
Ran Duan ◽  
Jianguo Sun

Regression analysis of multivariate interval-censored failure time data has been discussed by many authors1-6. For most of the existing methods, however, one limitation is that they only apply to the situation where the censoring is non-informative or the failure time of interest is independent of the censoring mechanism. It is apparent that this may not be true sometimes and as pointed out by some authors, the analysis that does not take the dependent censoring into account could lead to biased or misleading results7,8. In this study, we consider regression analysis of multivariate interval-censored data arising from the additive hazards model and propose an estimating equation-based approach that allows for the informative censoring. The method can be easily implemented and the asymptotic properties of the proposed estimator of regression parameters are established. Also we perform a simulation study for the evaluation of the proposed method and it suggests that the method works well for practical situations. Finally, the proposed approach is applied to a set of real data.


Author(s):  
Xinyan Zhang ◽  
Jianguo Sun

AbstractClustered interval-censored failure time data are commonly encountered in many medical settings. In such situations, one issue that often arises in practice is that the cluster size is related to the risk for the outcome of interest. It is well-known that ignoring the informativeness of the cluster size can result in biased parameter estimates. In this article, we consider regression analysis of clustered interval-censored data with informative cluster size with the focus on semiparametric methods. For the problem, two approaches are presented and investigated. One is a within-cluster resampling procedure and the other is a weighted estimating equation approach. Unlike previously published methods, the new approaches take into account cluster sizes and heterogeneous correlation structures without imposing strong parametric assumptions. A simulation experiment is carried out to evaluate the performance of the proposed approaches and indicates that they perform well for practical situations. The approaches are applied to a lymphatic filariasis study that motivated this study.


2021 ◽  
pp. 096228022110092
Author(s):  
Mingyue Du ◽  
Hui Zhao ◽  
Jianguo Sun

Cox’s proportional hazards model is the most commonly used model for regression analysis of failure time data and some methods have been developed for its variable selection under different situations. In this paper, we consider a general type of failure time data, case K interval-censored data, that include all of other types discussed as special cases, and propose a unified penalized variable selection procedure. In addition to its generality, another significant feature of the proposed approach is that unlike all of the existing variable selection methods for failure time data, the proposed approach allows dependent censoring, which can occur quite often and could lead to biased or misleading conclusions if not taken into account. For the implementation, a coordinate descent algorithm is developed and the oracle property of the proposed method is established. The numerical studies indicate that the proposed approach works well for practical situations and it is applied to a set of real data arising from Alzheimer’s Disease Neuroimaging Initiative study that motivated this study.


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