Molecular Modeling of Cytochrome P450 1A1: Enzyme-Substrate Interactions and Substrate Binding Affinities

2002 ◽  
Vol 20 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Grazyna D. Szklarz ◽  
Mark D. Paulsen
Keyword(s):  
Cytochrome P450 ◽  
Molecular Modeling ◽  
Substrate Binding ◽  
Binding Affinities ◽  
Cytochrome P450 1A1 ◽  
Substrate Interactions ◽  
Enzyme Substrate ◽  
Enzyme Substrate Interactions

Characterization of Substrate Binding to Cytochrome P450 1A1 Using Molecular Modeling and Kinetic Analyses: Case of Residue 382

2003 ◽  
Vol 31 (4) ◽  
pp. 412-420 ◽  
Author(s):  
Jianguo Liu ◽  
Spencer S. Ericksen ◽  
Dan Besspiata ◽  
Charles W. Fisher ◽  
Grazyna D. Szklarz
Keyword(s):  
Cytochrome P450 ◽  
Molecular Modeling ◽  
Substrate Binding ◽  
Cytochrome P450 1A1

Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea

RSC Advances ◽  
2014 ◽  
Vol 4 (107) ◽  
pp. 62321-62325 ◽  
Author(s):  
Wei Peng ◽  
Tzu-Ping Ko ◽  
Yunyun Yang ◽  
Yingying Zheng ◽  
Chun-Chi Chen ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Substrate Binding ◽  
Binding Mode ◽  
Specific Enzyme ◽  
Clonostachys Rosea ◽  
Substrate Interactions ◽  
Enzyme Substrate ◽  
Enzyme Substrate Interactions

The mycotoxin zearalenone binds to a deep pocket of the dimeric lactonase in a bent conformation, revealing specific enzyme–substrate interactions.

Roles of Individual Enzyme−Substrate Interactions by α-1,3-Galactosyltransferase in Catalysis and Specificity†,‡

Biochemistry ◽  
2003 ◽  
Vol 42 (46) ◽  
pp. 13512-13521 ◽  
Author(s):  
Yingnan Zhang ◽  
G. Jawahar Swaminathan ◽  
Ashlesha Deshpande ◽  
Ester Boix ◽  
Ramanathan Natesh ◽  
...  
Keyword(s):  
Substrate Interactions ◽  
Enzyme Substrate ◽  
Individual Enzyme ◽  
Enzyme Substrate Interactions

Dioxygenase fromAspergillus fumigatusMC8: molecular modelling andin silicostudies on enzyme–substrate interactions

2012 ◽  
Vol 38 (2) ◽  
pp. 144-151 ◽  
Author(s):  
Krishnankutty Roopesh ◽  
Joseph Abhilash ◽  
M. Haridas ◽  
Abdulhameed Sabu ◽  
Perraud Gaime Isabelle ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
Substrate Interactions ◽  
Enzyme Substrate ◽  
Enzyme Substrate Interactions
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