Is retinal nerve fibre layer thickness correlated with visual function in individuals having optic neuritis?

2021 ◽  
pp. 1-7
Author(s):  
Abbas Ali Yekta ◽  
Sara Sorouh ◽  
Amir Asharlous ◽  
Ali Mirzajani ◽  
Ebrahim Jafarzadehpur ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Visual Function ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

scholarly journals Correlation of Peripapillary Retinal Nerve Fibre Layer Thickness and Visual Evoked Potential in Optic Neuritis in a Tertiary Eye Care Centre

2019 ◽  
Vol 10 (2) ◽  
pp. 156-161
Author(s):  
Manita Sunam Godar ◽  
Ananda Kumar Sharma ◽  
Madhu Thapa ◽  
Sanjeeta Sitaula ◽  
Nita Sunam Gamal ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Visual Evoked Potential ◽  
Evoked Potential ◽  
Retinal Nerve Fibre Layer ◽  
P Value ◽  
Fibre Layer ◽  
The Mean ◽  
Nerve Fibre Layer

Introduction: Optic neuritis (ON) is the involvement of the optic nerve as a result of inflammation, demyelination or infection. Objective: To study the correlation between peripapillary retinal nerve fibre layer thickness (pRNFL) and visual evoked potential (VEP) in ON cases. Materials and Method: A non-interventional, descriptive, cross sectional study enrolling 66 eyes of 49 patients with ON was done. pRNFL thickness was measured by Optical Coherence Tomography (OCT) and VEP was also done. OCT and VEP findings were compared with the control group. In addition correlation between pRNFL thickness and VEP was done. Results: The mean pRNFL in affected eyes were significantly higher than the control superiorly (p-value<0.001), inferiorly (p-value <0.001), temporally (p-value 0.005) and nasally (p-value <0.001). The mean P100 latency in the affected eyes were significantly prolonged than the control eyes both at 1º (p-value<0.001) and at 15’ (p-value=0.05). The mean N75-P100 amplitude in the affected eyes were significantly reduced than the control eyes both at 1º (p-value<0.001) and at 15’ (p-value<0.001). The mean pRNFL thickness in all four quadrants and VEP findings of the affected eyes showed no significant correlation. Conclusion: The increased thickness in non-myelinated pRNFL has no correlation with the increased latency or decreased amplitude in cases of ON. However, OCT is seen as a useful tool in detecting and quantifying even subtle pRNFL changes in cases of optic neuritis.

scholarly journals Longitudinal Changes in Retinal Nerve Fibre Layer Thickness after an Isolated Unilateral Retrobulbar Optic Neuritis: 1-Year Results

2015 ◽  
Vol 39 (1) ◽  
pp. 22-25 ◽  
Author(s):  
Gordon S. K. Yau ◽  
Jacky W. Y. Lee ◽  
Patrick P. K. Lau ◽  
Victor T. Y. Tam ◽  
Winnie W. Y. Wong ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Longitudinal Changes ◽  
Fibre Layer ◽  
Retrobulbar Optic Neuritis ◽  
Nerve Fibre Layer

Influence of uveitis on Bruch’s membrane opening minimum rim width and retinal nerve fibre layer thickness measurements

2018 ◽  
Vol 103 (10) ◽  
pp. 1413-1417 ◽  
Author(s):  
Matthias F Kriegel ◽  
Arnd Heiligenhaus ◽  
Carsten Heinz
Keyword(s):  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Fibre Layer ◽  
Bruch’S Membrane Opening ◽  
Nerve Fibre Layer ◽  
Active Inflammation ◽  
The Impact

Background/aimsTo assess the impact of papillary leakage and active inflammation on optical coherence tomography (OCT)-based retinal nerve fibre layer thickness (RNFLT) and Bruch’s membrane opening minimum rim width (BMO-MRW) measurements in uveitic eyes with and without secondary glaucoma.MethodsProspective, single-centre analysis of patients with uveitis. All patients included received a fluorescein angiography examination and an OCT scan measuring the BMO-MRW and the RNFLT in three concentric peripapillary ring scans.ResultsOverall, 95 eyes of 56 patients were enrolled. Papillary leakage and active inflammation were present in 39 (41%) and 57 (60%) eyes, respectively. Twenty-one eyes were classified as glaucomatous; 10 of those glaucomatous eyes showed papillary leakage. Both BMO-MRW and RNFLT measurements were significantly increased in eyes with papillary leakage (BMO-MRW: p=0.0001; RNFLT: first to third ring (p<0.0001)). Active inflammation led to a significantly thickened RNFLT (first ring: p=0.0026; second ring: p=0.0009; third ring: p=0.0002) while only a trend towards increased values could be observed in the BMO-MRW measurements (p=0.3063). Glaucomatous eyes with papillary leakage demonstrated significantly higher values on both BMO-MRW and RNFLT measurements than glaucomatous eyes without leakage (BMO-MRW: p=0.0159; RNFLT: first ring: p=0.0062; second ring: p=0.0037; third ring: p=0.0197). No significant difference could be observed between glaucomatous eyes with leakage and non-glaucomatous eyes without leakage (BMO-MRW: p=0.4132; RNFLT: first ring: p=0.5412; second ring: p=0.3208; third ring: p=0.1164).ConclusionsThe OCT scanning parameters BMO-MRW and RNFLT were significantly influenced by papillary leakage in uveitic eyes with and without glaucoma. RNFLT values were also significantly increased while active inflammation was present. In patients with uveitis, these OCT-based imaging tools should be interpreted with caution, especially in those with papillary leakage or active inflammation.

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