scholarly journals Lupus-prone MRL/faslpr/lprmice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: Concurrent upregulation of somatic hypermutation and class switch DNA recombination

Autoimmunity ◽  
2009 ◽  
Vol 42 (2) ◽  
pp. 89-103 ◽  
Author(s):  
Hong Zan ◽  
Jinsong Zhang ◽  
Sona Ardeshna ◽  
Zhenming Xu ◽  
Seok-Rae Park ◽  
...  
Keyword(s):  
Somatic Hypermutation ◽  
Dna Recombination ◽  
Dna Lesions ◽  
Class Switch ◽  
Immunoglobulin Locus ◽  
Class Switch Dna Recombination

scholarly journals A Role for the MutL Mismatch Repair Mlh3 Protein in Immunoglobulin Class Switch DNA Recombination and Somatic Hypermutation

2006 ◽  
Vol 176 (9) ◽  
pp. 5426-5437 ◽  
Author(s):  
Xiaoping Wu ◽  
Connie Y. Tsai ◽  
Marienida B. Patam ◽  
Hong Zan ◽  
Jessica P. Chen ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Somatic Hypermutation ◽  
Dna Recombination ◽  
Immunoglobulin Class ◽  
Class Switch ◽  
Class Switch Dna Recombination

scholarly journals HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

2009 ◽  
Vol 10 (5) ◽  
pp. 540-550 ◽  
Author(s):  
Seok-Rae Park ◽  
Hong Zan ◽  
Zsuzsanna Pal ◽  
Jinsong Zhang ◽  
Ahmed Al-Qahtani ◽  
...  
Keyword(s):  
Somatic Hypermutation ◽  
Cytidine Deaminase ◽  
Dna Recombination ◽  
Class Switch ◽  
Class Switch Dna Recombination

scholarly journals Regulation of aicda Expression and AID Activity: Relevance to Somatic Hypermutation and Class Switch DNA Recombination

2007 ◽  
Vol 27 (4) ◽  
pp. 367-397 ◽  
Author(s):  
Zhenming Xu ◽  
Egest J. Pone ◽  
Ahmed Al-Qahtani ◽  
Seok-Rae Park ◽  
Hong Zan ◽  
...  
Keyword(s):  
Somatic Hypermutation ◽  
Dna Recombination ◽  
Class Switch ◽  
Class Switch Dna Recombination

scholarly journals The Activation-induced Deaminase Functions in a Postcleavage Step of the Somatic Hypermutation Process

2002 ◽  
Vol 195 (9) ◽  
pp. 1193-1198 ◽  
Author(s):  
F. Nina Papavasiliou ◽  
David G. Schatz
Keyword(s):  
Somatic Hypermutation ◽  
Cytidine Deaminase ◽  
Point Mutations ◽  
Dna Lesions ◽  
Dominant Negative ◽  
Constant Region ◽  
Region Gene ◽  
Variable Regions ◽  
Class Switch ◽  
Activation Induced Deaminase

Activation of B cells by antigen fuels two distinct molecular modifications of immunoglobulin (Ig) genes. Class-switch recombination (CSR) replaces the Igμ heavy chain constant region with a downstream constant region gene, thereby altering the effector function of the resulting antibodies. Somatic hypermutation (SHM) introduces point mutations into the variable regions of Ig genes, thereby changing the affinity of antibody for antigen. Mechanistic overlap between the two reactions has been suggested by the finding that both require the activation-induced cytidine deaminase (AID). It has been proposed that AID initiates both CSR and SHM by activating a common nuclease. Here we provide evidence that cells lacking AID, or expressing a dominant negative form of the protein, are still able to incur DNA lesions in SHM target sequences. The results indicate that an intact cytidine deaminase motif is required for AID function, and that AID acts downstream of the initial DNA lesions in SHM.

Sign in / Sign up

Export Citation Format

Share Document