Choroidal Structural Changes in Sympathetic Ophthalmia on Swept-Source Optical Coherence Tomography

Abstract Background Structural changes of the choroid, such as choroidal thickening, have been indicated in amblyopic eyes with hyperopic anisometropia as compared to fellow or healthy eyes. The purpose of the present study was to investigate choroidal vascular density (CVD) in children with unilateral hyperopic amblyopia.Methods This study included 88 eyes of 44 patients with unilateral amblyopia due to hyperopic anisometropia with or without strabismus and 29 eyes of 29 age-matched normal controls. The CVD of Haller's layer was quantified from en-face images constructed by 3-dimensional swept-source optical coherence tomography images flattened relative to Bruch's membrane. The analysis area was a 3×3-mm square of macula after magnification correction. Relationships between CVD and other parameters [best-corrected visual acuity (BCVA), refractive error and subfoveal choroidal thickness (SFCT)] were investigated, and CVDs were compared between amblyopic, fellow, and normal control eyes.Results Mean CVD was 59.11 ± 0.66% in amblyopic eyes, 59.23 ± 0.81% in fellow eyes, and 59.29 ± 0.74% in normal control eyes. CVD showed a significant positive relationship with SFCT (p=0.004), but no relationships with other parameters. No significant differences in CVD were evident among amblyopic, fellow, and normal control eyes after adjusting for SFCT (p=0.502).Conclusions CVD was unrelated to BCVA, and CVD did not differ significantly among amblyopic, fellow and normal control eyes. These results suggest that the local CVD of Haller's layer is unaffected in unilateral hyperopic amblyopic eyes.

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Pilot study assessing the structural changes in posttrabecular aqueous humor outflow pathway after trabecular meshwork surgery using swept-source optical coherence tomography

PLoS ONE ◽

10.1371/journal.pone.0199739 ◽

2018 ◽

Vol 13 (6) ◽

pp. e0199739 ◽

Cited By ~ 5

Author(s):

Munemitsu Yoshikawa ◽

Tadamichi Akagi ◽

Akihito Uji ◽

Hideo Nakanishi ◽

Takanori Kameda ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Pilot Study ◽

Aqueous Humor ◽

Trabecular Meshwork ◽

Structural Changes ◽

Optical Coherence ◽

Swept Source ◽

Aqueous Humor Outflow ◽

Outflow Pathway

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Choroidal vessel density in unilateral hyperopic amblyopia using en-face optical coherence tomography

BMC Ophthalmology ◽

10.1186/s12886-020-01735-z ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Syunsuke Araki ◽

Atsushi Miki ◽

Katsutoshi Goto ◽

Tsutomu Yamashita ◽

Tsuyoshi Yoneda ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Normal Control ◽

Structural Changes ◽

Vascular Density ◽

Optical Coherence ◽

Swept Source ◽

3 Dimensional ◽

Face Images ◽

En Face ◽

Normal Controls

Abstract Background Structural changes of the choroid, such as choroidal thickening, have been indicated in amblyopic eyes with hyperopic anisometropia as compared to fellow or healthy eyes. The purpose of the present study was to investigate choroidal vascular density (CVD) in children with unilateral hyperopic amblyopia. Methods This study included 88 eyes of 44 patients with unilateral amblyopia due to hyperopic anisometropia with or without strabismus and 29 eyes of 29 age-matched normal controls. The CVD of Haller’s layer was quantified from en-face images constructed by 3-dimensional swept-source optical coherence tomography images flattened relative to Bruch’s membrane. The analysis area was a 3 × 3-mm square of macula after magnification correction. Relationships between CVD and other parameters [best-corrected visual acuity (BCVA), refractive error and subfoveal choroidal thickness (SFCT)] were investigated, and CVDs were compared between amblyopic, fellow, and normal control eyes. Results Mean CVD was 59.11 ± 0.66% in amblyopic eyes, 59.23 ± 0.81% in fellow eyes, and 59.29 ± 0.74% in normal control eyes. CVD showed a significant positive relationship with SFCT (p = 0.004), but no relationships with other parameters. No significant differences in CVD were evident among amblyopic, fellow, and normal control eyes after adjusting for SFCT (p = 0.502). Conclusions CVD was unrelated to BCVA, and CVD did not differ significantly among amblyopic, fellow and normal control eyes. These results suggest that the local CVD of Haller’s layer is unaffected in unilateral hyperopic amblyopic eyes.

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Choroidal Structural Changes Assessed with Swept-Source Optical Coherence Tomography after Cataract Surgery in Eyes with Diabetic Retinopathy

Journal of Ophthalmology ◽

10.1155/2020/5839837 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Huiping Yao ◽

Sha Gao ◽

Xiaoqing Liu ◽

Yufeng Zhou ◽

Yu Cheng ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Diabetic Retinopathy ◽

Cataract Surgery ◽

Structural Changes ◽

Control Group ◽

Optical Coherence ◽

Diabetic Cataract ◽

Swept Source ◽

Choroidal Vasculature ◽

The Difference

Objective. To determine the influence of phacoemulsification on choroidal vasculature in patients with diabetic retinopathy (DR) undergoing cataract surgery using swept-source optical coherence tomography (SS-OCT). Methods. The study was conducted in 23 eyes of 23 cataract patients with mild/moderate nonproliferative diabetic retinopathy (NPDR) without diabetic macular edema (DME) and 23 age-matched controls. Choroidal thickness (CT) and choroidal vascularity index (CVI) were measured at baseline and 1 week, 1 month, and 3 months after surgery. Results. The baseline CVI in the DR group was significantly lower than that in the control group ( P = 0.001 ). CVI in DR patients after surgery significantly increased compared with preoperative values (all P < 0.001 for 1 week, 1 month, and 3 months after surgery). Postoperative increase of CVI and CT in the DR group was more than in the control group, and the difference was significant 1 month and 3 months after surgery (all P < 0.05 ). Conclusion. Patients with mild/moderate NPDR have reduced CVI compared with nondiabetic patients at baseline; diabetic cataract surgery tended to induce more increase in CVI and CT as compared with nondiabetic patients. This trial is registered with NCT04499768.

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Probing temporal structural changes within cornea using 200 kHz swept source nano sensitive optical coherence tomography (nsOCT)

Dynamics and Fluctuations in Biomedical Photonics XVII ◽

10.1117/12.2553024 ◽

2020 ◽

Author(s):

Cerine Lal ◽

Sergey Alexandrov ◽

Sweta Rani ◽

Thomas Ritter ◽

Martin Leahy

Keyword(s):

Optical Coherence Tomography ◽

Structural Changes ◽

Optical Coherence ◽

Swept Source

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Choroidal vessel density in unilateral hyperopic amblyopia using en-face optical coherence tomography

10.21203/rs.3.rs-53300/v2 ◽

2020 ◽

Author(s):

Syunsuke Araki ◽

Atsushi Miki ◽

Katsutoshi Goto ◽

Tsutomu Yamashita ◽

Tsuyoshi Yoneda ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Normal Control ◽

Structural Changes ◽

Vascular Density ◽

Optical Coherence ◽

Swept Source ◽

3 Dimensional ◽

Face Images ◽

En Face ◽

Normal Controls

Abstract Background Structural changes of the choroid, such as choroidal thickening, have been indicated in amblyopic eyes with hyperopic anisometropia as compared to fellow or healthy eyes. The purpose of the present study was to investigate choroidal vascular density (CVD) in children with unilateral hyperopic amblyopia.Methods This study included 88 eyes of 44 patients with unilateral amblyopia due to hyperopic anisometropia with or without strabismus and 29 eyes of 29 age-matched normal controls. The CVD of Haller's layer was quantified from en-face images constructed by 3-dimensional swept-source optical coherence tomography images flattened relative to Bruch's membrane. The analysis area was a 3×3-mm square of macula after magnification correction. Relationships between CVD and other parameters [best-corrected visual acuity (BCVA), refractive error, axial length and subfoveal choroidal thickness (SFCT)] were investigated, and CVDs were compared between amblyopic, fellow, and normal control eyes.Results Mean CVD was 59.11 ± 0.66% in amblyopic eyes, 59.23 ± 0.81% in fellow eyes, and 59.29 ± 0.74% in normal control eyes. CVD showed a significant positive relationship with SFCT (p=0.005), but no relationships with other parameters. No significant differences in CVD were evident among amblyopic, fellow, and normal control eyes after adjusting for SFCT (p=0.502).Conclusions CVD was unrelated to BCVA, and CVD did not differ significantly among amblyopic, fellow and normal control eyes. These results suggest that the local CVD of Haller's layer is unaffected in unilateral hyperopic amblyopic eyes.

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Choroidal Vessel Density in Unilateral Hyperopic Amblyopia Using en-Face Optical Coherence Tomography

10.21203/rs.3.rs-53300/v1 ◽

2020 ◽

Author(s):

Syunsuke Araki ◽

Atsushi Miki ◽

Katsutoshi Goto ◽

Tsutomu Yamashita ◽

Tsuyoshi Yoneda ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Normal Control ◽

Structural Changes ◽

Vascular Density ◽

Optical Coherence ◽

Swept Source ◽

3 Dimensional ◽

Face Images ◽

En Face ◽

Normal Controls

Abstract BackgroundStructural changes of the choroid, such as choroidal thickening, have been indicated in amblyopic eyes with hyperopic anisometropia as compared to fellow or healthy eyes. The purpose of the present study was to investigate choroidal vascular density (CVD) in children with unilateral hyperopic amblyopia.MethodsThis study included 88 eyes of 44 patients with unilateral amblyopia due to hyperopic anisometropia with or without strabismus and 29 eyes of 29 age-matched normal controls. The CVD of Haller's layer was quantified from en-face images constructed by 3-dimensional swept-source optical coherence tomography images flattened relative to Bruch's membrane. The analysis area was a 3×3-mm square of macula after magnification correction. Relationships between CVD and other parameters [best-corrected visual acuity (BCVA), refractive error, axial length and subfoveal choroidal thickness (SFCT)] were investigated, and CVDs were compared between amblyopic, fellow, and normal control eyes.ResultsMean CVD was 59.1±0.7% in amblyopic eyes, 59.2±0.8% in fellow eyes, and 59.3±0.7% in normal control eyes. CVD showed a significant positive relationship with SFCT (p=0.005), but no relationships with other parameters. No significant differences in CVD were evident among amblyopic, fellow, and normal control eyes after adjusting for SFCT (p=0.502).ConclusionsCVD was unrelated to BCVA, and CVD did not differ significantly among amblyopic, fellow and normal control eyes. These results suggest that the local CVD of Haller's layer is unaffected in unilateral hyperopic amblyopic eyes.

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