Sensory processing differences are reported in a high proportion of children with fetal alcohol spectrum disorders (FASD), but how these problems impact caregiver burden has not been investigated. Linear regression was used to examine the association between parenting stress and problems in sensory processing, along with other child and family characteristics, among 52 children aged 5 to 12 years with FASD. Participants also had clinically significant problem behaviors. Higher levels of child-related parenting stress were moderately correlated with more parent-reported sensory processing problems ( r = −.60). Regression findings revealed that parent-reported problems in children's behavior regulation, an aspect of executive function, and sensory processing deficits were the strongest predictors of child-related parenting stress, together accounting for 62% of variance. Children's sensory processing deficits and executive function impairments affect the parent—child system and should be central considerations when developing family-centered supports for children with FASD.