Zinc sulfamate (Zn(NH2SO3)2 is a derivative of sulfamic acid (H3NSO3) which possesses
“Lewis acidity” and finds well suited in a number of catalytic applications. The present paper describes
an efficient, eco-friendly, and clean synthesis of 2-substituted benzimidazole derivatives by reacting
diverse o-phenylenediamine with various substituted aromatic aldehydes using a catalytic amount of
zinc sulfamate in ethanol at ambient temperature. As a result, 10 mol.% of Zinc sulfamate catalyst
showed 92% of respective product yield with 100% conversion using short reaction period in ethanol.
Meanwhile, effect of reaction parameters, such as amount of catalyst, different solvents, and reaction
temperature on reaction product, was also studied. In addition, in the optimized reaction condition
various substituted biological important benzimidazoles derivatives were prepared by using optimized
reaction condition in good to efficient yield. In addition, possible reaction mechanism in the presence
of zinc sulfamate for the preparation of benzimidazole derivative was sketched and discussed. The present
green approach showed significances with faster reaction rate with inexpensive catalyst, which
showed excellent and clean yield of benzimidazole in mild reaction condition with easy work-up procedure.
