scholarly journals MOG79–90 Peptide in Complex with Recombinant MHC Class II Molecules Ameliorates Experimental Autoimmune Encephalomyelitis

2010 ◽  
Vol 24 (sup1) ◽  
pp. 107-112
Author(s):  
T. Batsalova ◽  
M. Vestberg ◽  
R. Holmdahl ◽  
B. Dzhambazov
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Autoimmune Encephalomyelitis ◽  
Mhc Class Ii Molecules ◽  
Experimental Autoimmune

scholarly journals Analysis of Autoreactive CD4 T Cells in Experimental Autoimmune Encephalomyelitis after Primary and Secondary Challenge Using MHC Class II Tetramers

2004 ◽  
Vol 172 (5) ◽  
pp. 2878-2884 ◽  
Author(s):  
Felix Bischof ◽  
Matthias Hofmann ◽  
Ton N. M. Schumacher ◽  
Florry A. Vyth-Dreese ◽  
Robert Weissert ◽  
...  
Keyword(s):  
T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Mhc Class Ii ◽  
Cd4 T Cells ◽  
Class Ii ◽  
Autoimmune Encephalomyelitis ◽  
Secondary Challenge ◽  
Experimental Autoimmune

scholarly journals Microglial MHC class II is dispensable for experimental autoimmune encephalomyelitis and cuprizone-induced demyelination

2018 ◽  
Vol 48 (8) ◽  
pp. 1308-1318 ◽  
Author(s):  
Yochai Wolf ◽  
Anat Shemer ◽  
Liron Levy-Efrati ◽  
Mor Gross ◽  
Jung-Seok Kim ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

scholarly journals Transgenic Interleukin 10 Prevents Induction of Experimental Autoimmune Encephalomyelitis

1999 ◽  
Vol 189 (6) ◽  
pp. 1005-1010 ◽  
Author(s):  
Daniel J. Cua ◽  
Herve Groux ◽  
David R. Hinton ◽  
Stephen A. Stohlman ◽  
Robert L. Coffman
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Transgenic Mice ◽  
Mhc Class Ii ◽  
Cell Function ◽  
Class Ii ◽  
Interleukin 10 ◽  
T Helper 1 ◽  
Autoimmune Encephalomyelitis ◽  
Autoreactive T Cell ◽  
Experimental Autoimmune

The effectiveness of interleukin 10 (IL-10) in the treatment of autoimmune-mediated central nervous system inflammation is controversial. Studies of the model system, experimental autoimmune encephalomyelitis (EAE), using various routes, regimens, and delivery methods of IL-10 suggest that these variables may affect its immunoregulatory function. To study the influence of these factors on IL-10 regulation of EAE pathogenesis, we have analyzed transgenic mice expressing human IL-10 (hIL-10) transgene under the control of a class II major histocompatibility complex (MHC) promoter. The hIL-10 transgenic mice are highly resistant to EAE induced by active immunization, and this resistance appears to be mediated by suppression of autoreactive T cell function. Myelin-reactive T helper 1 cells are induced but nonpathogenic in the IL-10 transgenic mice. Antibody depletion confirmed that EAE resistance is dependent on the presence of the transgenic IL-10. Mice expressing the hIL-10 transgene but not the endogenous murine IL-10 gene demonstrated that transgenic IL-10 from MHC class II–expressing cells is sufficient to block induction of EAE. This study demonstrates that IL-10 can prevent EAE completely if present at appropriate levels and times during disease induction.

scholarly journals Experimental autoimmune encephalomyelitis in mice expressing the autoantigen MBP1–10 covalently bound to the MHC class II molecule I-Au

2005 ◽  
Vol 18 (1) ◽  
pp. 151-162 ◽  
Author(s):  
Florian C. Kurschus ◽  
Thilo Oelert ◽  
Birgit Liliensiek ◽  
Pascale Buchmann ◽  
David C. Wraith ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune ◽  
Covalently Bound

scholarly journals MHC Class II Isotype- and Allele-Specific Attenuation of Experimental Autoimmune Encephalomyelitis

2004 ◽  
Vol 173 (4) ◽  
pp. 2792-2802 ◽  
Author(s):  
Katrien L. de Graaf ◽  
Silvia Barth ◽  
Martin M. Herrmann ◽  
Maria K. Storch ◽  
Christoph Otto ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Autoimmune Encephalomyelitis ◽  
Specific Attenuation ◽  
Allele Specific ◽  
Experimental Autoimmune
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