Breakthrough therapy designation of nirsevimab for the prevention of lower respiratory tract illness caused by respiratory syncytial virus infections (RSV)

2021 ◽  
Author(s):  
Harrison C. Bergeron ◽  
Ralph A. Tripp
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Virus Infections ◽  
Respiratory Syncytial Virus Infections ◽  
Respiratory Tract Illness ◽  
Syncytial Virus

scholarly journals In SilicoApproach towards Designing Virtual Oligopeptides for HRSV

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Ruchi Jain ◽  
Shanmughavel Piramanayagam
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Virus Replication ◽  
Lower Respiratory Tract ◽  
Specific Interaction ◽  
Infection Process ◽  
Rational Choices ◽  
Respiratory Tract Illness ◽  
Syncytial Virus ◽  
Infants And Young Children

HRSV (human respiratory syncytial virus) is a serious cause of lower respiratory tract illness in infants and young children. Designing inhibitors from the proteins involved in virus replication and infection process provides target for new therapeutic treatments. In the present study,in silicodocking was performed using motavizumab as a template to design motavizumab derived oligopeptides for developing novel anti-HRSV agents. Additional simulations were conducted to study the conformational propensities of the oligopeptides and confirmed the hypothesis that the designed oligopeptide is highly flexible and capable of assuming stable confirmation. Our study demonstrated the best specific interaction of GEKKLVEAPKS oligopeptide for glycoprotein strain A among various screened oligopeptides. Encouraged by the results, we expect that the proposed scheme will provide rational choices for antibody reengineering which is useful for systematically identifying the possible ways to improve efficacy of existing antibody drugs.

Serious Early Childhood Wheezing After Respiratory Syncytial Virus Lower Respiratory Tract Illness in Preterm Infants

2010 ◽  
Vol 32 (14) ◽  
pp. 2422-2432 ◽  
Author(s):  
José R. Romero ◽  
Dan L. Stewart ◽  
Erin K. Buysman ◽  
Ancilla W. Fernandes ◽  
Hasan S. Jafri ◽  
...  
Keyword(s):  
Early Childhood ◽  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Preterm Infants ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Illness ◽  
Syncytial Virus
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