scholarly journals Adeno-Associated Virus (AAV) gene therapy for cystic fibrosis: current barriers and recent developments

2017 ◽  
Vol 17 (10) ◽  
pp. 1265-1273 ◽  
Author(s):  
William B. Guggino ◽  
Liudmila Cebotaru
Keyword(s):  
Cystic Fibrosis ◽  
Gene Therapy ◽  
Adeno Associated Virus ◽  
Recent Developments

scholarly journals Overcoming the Cystic Fibrosis Sputum Barrier to Leading Adeno-associated Virus Gene Therapy Vectors

2014 ◽  
Vol 22 (8) ◽  
pp. 1484-1493 ◽  
Author(s):  
Benjamin S Schuster ◽  
Anthony J Kim ◽  
Joshua C Kays ◽  
Mia M Kanzawa ◽  
William B Guggino ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Gene Therapy ◽  
Adeno Associated Virus ◽  
Virus Gene ◽  
Cystic Fibrosis Sputum ◽  
Gene Therapy Vectors

scholarly journals Gene therapy for cystic fibrosis: new tools for precision medicine

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jin-A Lee ◽  
Alex Cho ◽  
Elena N. Huang ◽  
Yiming Xu ◽  
Henry Quach ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Gene Therapy ◽  
Animal Models ◽  
Precision Medicine ◽  
Gene Targeting ◽  
New Models ◽  
Recent Developments ◽  
The Mean ◽  
Insight Into ◽  
The Way

AbstractThe discovery of the Cystic fibrosis (CF) gene in 1989 has paved the way for incredible progress in treating the disease such that the mean survival age of individuals living with CF is now ~58 years in Canada. Recent developments in gene targeting tools and new cell and animal models have re-ignited the search for a permanent genetic cure for all CF. In this review, we highlight some of the more recent gene therapy approaches as well as new models that will provide insight into personalized therapies for CF.

Gene Therapy with Adeno-associated Virus for Cystic Fibrosis

2016 ◽  
Vol 193 (3) ◽  
pp. 234-236 ◽  
Author(s):  
Rajvinder Karda ◽  
Suzanne M. K. Buckley ◽  
Simon N. Waddington
Keyword(s):  
Cystic Fibrosis ◽  
Gene Therapy ◽  
Adeno Associated Virus

Prevalence of Neutralizing Antibodies Against Adeno-Associated Virus (AAV) Types 2, 5, and 6 in Cystic Fibrosis and Normal Populations: Implications for Gene Therapy Using AAV Vectors

2006 ◽  
Vol 0 (0) ◽  
pp. 060307123505001 ◽  
Author(s):  
Christine L. Halbert ◽  
A. Dusty Miller ◽  
Sharon McNamara ◽  
Julia Emerson ◽  
Ronald L. Gibson ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Gene Therapy ◽  
Neutralizing Antibodies ◽  
Adeno Associated Virus ◽  
Normal Populations
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