Design, synthesis and in vitro antiproliferative activity of new thiazolidinedione-1,3,4-oxadiazole hybrids as thymidylate synthase inhibitors

Design Synthesis ◽

Design, Synthesis, and In Vitro Evaluation of Tubulin‐targeting Dibenzothiazines with Antiproliferative Activity as Novel Heterocycle Building Block

ChemMedChem ◽

10.1002/cmdc.202100383 ◽

2021 ◽

Author(s):

Walter Damián Guerra ◽

Daniel Lucena-Agell ◽

Rafael Hortigüela ◽

Roberto Arturo Rossi ◽

J. Fernando Díaz ◽

...

Keyword(s):

Building Block ◽

Design Synthesis ◽

In Vitro Evaluation

Thymidylate synthase inhibitors: The in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates

Advances in Enzyme Regulation ◽

10.1016/0065-2571(91)90006-8 ◽

1991 ◽

Vol 31 ◽

pp. 13-27 ◽

Cited By ~ 29

Author(s):

A.L. Jackman ◽

P.R. Marsham ◽

R.G. Moran ◽

R. Kimbell ◽

B.M. O'Connor ◽

...

Keyword(s):

Thymidylate Synthase ◽

Vitro Activity ◽

In Vitro Activity ◽

Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116136 ◽

2021 ◽

pp. 116136

Author(s):

Mohammad Mahboob Alam ◽

Azizah M. Malebari ◽

Syed Nazreen ◽

Thikryat Neamatallah ◽

Abdulraheem SA Almalki ◽

...

Keyword(s):

Breast Cancer ◽

Molecular Docking ◽

Cancer Cells ◽

Thymidylate Synthase ◽

Breast Cancer Cells ◽

Docking Studies ◽

Design Synthesis ◽

Molecular Docking Studies ◽

Advances in Experimental Medicine and Biology - Chemistry and Biology of Pteridines and Folates ◽

Use of Murine L5178Y Lymphoma Thymidine Kinase Mutants for in Vitro and in Vivo Antitumour Efficacy Evaluation of Novel Thymidylate Synthase Inhibitors

10.1007/978-1-4615-2960-6_120 ◽

1993 ◽

pp. 589-592 ◽

Cited By ~ 8

Author(s):

T. C. Stephens ◽

M. N. Smith ◽

S. E. Waterman ◽

M. L. McCloskey ◽

A. L. Jackman ◽

...

Keyword(s):

Thymidine Kinase ◽

Thymidylate Synthase ◽

Efficacy Evaluation ◽

A novel cluster of C5-curcuminoids: design, synthesis, in vitro antiproliferative activity and DNA binding of bis(arylidene)-4-cyclanone derivatives based on 4-hydroxycyclohexanone scaffold

Research on Chemical Intermediates ◽

10.1007/s11164-019-03859-4 ◽

2019 ◽

Vol 45 (9) ◽

pp. 4711-4735 ◽

Cited By ~ 2

Author(s):

Imre Huber ◽

István Zupkó ◽

András Gyovai ◽

Péter Horváth ◽

Eszter Kiss ◽

...

Keyword(s):

Dna Binding ◽

Design, synthesis, in vitro potent antiproliferative activity, and kinase inhibitory effects of new triarylpyrazole derivatives possessing different heterocycle terminal moieties

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/14756366.2019.1653292 ◽

2019 ◽

Vol 34 (1) ◽

pp. 1534-1543 ◽

Cited By ~ 2

Author(s):

Mahmoud M. Gamal El-Din ◽

Mohammed I. El-Gamal ◽

Mohammed S. Abdel-Maksoud ◽

Kyung Ho Yoo ◽

Chang-Hyun Oh

Keyword(s):

Inhibitory Effects ◽

Bisbenzoxazole Derivatives: Design, Synthesis, in Vitro Antimicrobial, Antiproliferative Activity, and Molecular Docking Studies

Polycyclic Aromatic Compounds ◽

10.1080/10406638.2020.1852589 ◽

2020 ◽

pp. 1-20

Author(s):

Ronak Haj Ersan ◽

Mehmet Abdullah Alagoz ◽

Aylin Dogen ◽

Nizami Duran ◽

Serdar Burmaoglu ◽

...

Keyword(s):

Molecular Docking ◽

Docking Studies ◽

Design Synthesis ◽

Molecular Docking Studies

Design, synthesis, in-vitro antiproliferative activity and kinase profile of new picolinamide based 2-amido and ureido quinoline derivatives

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2015.07.025 ◽

2015 ◽

Vol 101 ◽

pp. 754-768 ◽

Cited By ~ 24

Author(s):

Ashraf Kareem El-Damasy ◽

Seon Hee Seo ◽

Nam-Chul Cho ◽

Soon Bang Kang ◽

Ae Nim Pae ◽

...

Keyword(s):

Quinoline Derivatives ◽

Design, synthesis, and in vitro antiproliferative activity of novel Dasatinib derivatives

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2011.12.070 ◽

2012 ◽

Vol 22 (2) ◽

pp. 806-810 ◽

Cited By ~ 11

Author(s):

Jin Cai ◽

Shaoning Zhang ◽

Ming Zheng ◽

Xiaoqing Wu ◽

Junqing Chen ◽

...

Keyword(s):

Synthesis of Nonclassical Quinazolinone Antifolates as Thymidylate Synthase Inhibitors and Their Antitumor Activity In Vitro

Bulletin of the Korean Chemical Society ◽

10.5012/bkcs.2004.25.12.1898 ◽

2004 ◽

Vol 25 (12) ◽

pp. 1898-1906 ◽

Cited By ~ 4

Keyword(s):

Antitumor Activity ◽

Thymidylate Synthase ◽