An update on the potential role of intestinal first-pass metabolism for the prediction of drug–drug interactions: the role of PBPK modeling

2018 ◽  
Vol 14 (6) ◽  
pp. 625-634 ◽  
Author(s):  
Saeed Alqahtani ◽  
Ishfaq Bukhari ◽  
Ahmed Albassam ◽  
Maha Alenazi
Keyword(s):  
Drug Interactions ◽  
Potential Role ◽  
Pbpk Modeling ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism

Role of Intestinal First-Pass Metabolism of Baicalein in its Absorption Process

2005 ◽  
Vol 22 (7) ◽  
pp. 1050-1058 ◽  
Author(s):  
Li Zhang ◽  
Ge Lin ◽  
Qi Chang ◽  
Zhong Zuo
Keyword(s):  
Absorption Process ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism

scholarly journals CRITICAL ANALYSIS OF PURVA KARMA PRIOR TO NASYA W.S.R. SNEHA NASYA

2020 ◽  
pp. 94-97
Author(s):  
Divya Virupaksha ◽  
Krishnan N ◽  
Ajoy Viswam ◽  
Naveen B. S
Keyword(s):  
The Body ◽  
Nasal Delivery ◽  
Drug Preparation ◽  
Drug Degradation ◽  
First Pass Metabolism ◽  
First Pass ◽  
Gastro Intestinal Tract ◽  
Slow Absorption ◽  
Pass Metabolism

Ayurveda Panchakarmas are an all-time big name for both Ayurveda doctors and patients. Their efficacy of targeting the body holistically and evacuating toxins, thereby, addressing most of the problems of an individual makes it a hit. This paper aims at estimating the contribution of Purva Karma (procedures prior to instillation of medicine) in the outcome, especially in the context of Sneha Nasya (instillation of unctuous medicine). Nasal route of administration may help address the hitches accompanying to poor bioavailability, slow absorption, drug degradation, and possible adverse events in the gastro intestinal tract and avoids the first-pass metabolism in the liver. However, when considering nasal delivery, appropriate measures need to be taken to address the limitations of drug delivery in this region. Purva Karma starts with drug preparation and ends with stage of instillation of medicine (8 check points). The role of each of them on overcoming the limitations and delivering the results is reviewed.

The Use of 1-Aminobenzotriazole in Differentiating the Role of CYPMediated First Pass Metabolism and Absorption in Limiting Drug Oral Bioavailability: A Case Study

2008 ◽  
Vol 2 (2) ◽  
pp. 120-124 ◽  
Author(s):  
Ayman El-Kattan ◽  
Julie Poe ◽  
Lisa Buchholz ◽  
Hayden Thomas ◽  
Joanne Brodfuehrer ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism
Sign in / Sign up

Export Citation Format

Share Document