<p><strong>Aim.</strong> The aim of the study was to evaluate a prototype of a delivery system for transcatheter mitral valve replacement in vitro and in laboratory animal implantation. <br /><strong>Methods.</strong> The prototypes of the delivery system and transcatheter mitral valve prosthesis were evaluated in vitro in an isolated pig heart using transapical access. In an experiment on a large laboratory animal implantation was performed using transatrial access.<br /><strong>Results.</strong> It was found out that the prototype of the delivery system allows to adequately deliver and release the transcatheter prosthesis in implantation zone using transatrial and transapical approaches without frame deformation and valve dysfunction. <br />Conclusion. The delivery system prototype for transcatheter mitral valve replacement demonstrated satisfactory characteristics during in vitro experiment and large laboratory animal implantation.</p><p>Received 26 November 2018. Revised 17 December 2018. Accepted 21 December 2018.</p><p><strong>Funding:</strong> The study was carried out with the support of a grant of the Russian Science Foundation No. 16-15-10315.</p><p><strong>Conflict of interest:</strong> Author declare no conflict of interest.</p><p><strong>Author contributions</strong><br />Conception and study design: I.Y. Zhuravleva <br />Data collection and analysis: T.P. Timchenko, M.A. Ovcharov, E.V. Boyarkin <br />Drafting the article: R.M. Sharifulin, I.S. Zykov <br />Critical revision of the article: A.V. Bogachev-Prokophiev, A.M. Karaskov<br />Final approval of the version to be published: R.M. Sharifulin, A.V. Bogachev-Prokophiev, I.Y. Zhuravleva, T.P. Timchenko, I.S. Zykov, E.V. Boyarkin, M.A. Ovcharov, A.M. Karaskov</p>
Anterior Leaflet Laceration to Prevent Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Replacement