scholarly journals Testing of delivery system for transcatheter mitral valve implantation

2018 ◽  
Vol 22 (4) ◽  
pp. 80
Author(s):  
R. M. Sharifulin ◽  
A. V. Bogachev-Prokophiev ◽  
I. Yu. Zhuravleva ◽  
T. P. Timchenko ◽  
I. S. Zykov ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Delivery System ◽  
Conflict Of Interest ◽  
Laboratory Animal ◽  
Valve Prosthesis ◽  
Transcatheter Mitral Valve Replacement ◽  
Animal Implantation

<p><strong>Aim.</strong> The aim of the study was to evaluate a prototype of a delivery system for transcatheter mitral valve replacement in vitro and in laboratory animal implantation. <br /><strong>Methods.</strong> The prototypes of the delivery system and transcatheter mitral valve prosthesis were evaluated in vitro in an isolated pig heart using transapical access. In an experiment on a large laboratory animal implantation was performed using transatrial access.<br /><strong>Results.</strong> It was found out that the prototype of the delivery system allows to adequately deliver and release the transcatheter prosthesis in implantation zone using transatrial and transapical approaches without frame deformation and valve dysfunction. <br />Conclusion. The delivery system prototype for transcatheter mitral valve replacement demonstrated satisfactory characteristics during in vitro experiment and large laboratory animal implantation.</p><p>Received 26 November 2018. Revised 17 December 2018. Accepted 21 December 2018.</p><p><strong>Funding:</strong> The study was carried out with the support of a grant of the Russian Science Foundation No. 16-15-10315.</p><p><strong>Conflict of interest:</strong> Author declare no conflict of interest.</p><p><strong>Author contributions</strong><br />Conception and study design: I.Y. Zhuravleva <br />Data collection and analysis: T.P. Timchenko, M.A. Ovcharov, E.V. Boyarkin <br />Drafting the article: R.M. Sharifulin, I.S. Zykov <br />Critical revision of the article: A.V. Bogachev-Prokophiev, A.M. Karaskov<br />Final approval of the version to be published: R.M. Sharifulin, A.V. Bogachev-Prokophiev, I.Y. Zhuravleva, T.P. Timchenko, I.S. Zykov, E.V. Boyarkin, M.A. Ovcharov, A.M. Karaskov</p>

Modeling Transcatheter Mitral Valve Replacement with Anterior Leaflet Laceration using In Vitro and Computational Paradigms

2020 ◽  
Vol 4 (sup1) ◽  
pp. 78-78
Author(s):  
Keshav Kohli ◽  
Thomas Easley ◽  
Zhenglun Alan Wei ◽  
Vahid Sadri ◽  
John Lisko ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Anterior Leaflet ◽  
Transcatheter Mitral Valve Replacement

scholarly journals Tip-to-Base LAMPOON for Transcatheter Mitral Valve Replacement With a Protected Mitral Annulus

2021 ◽  
Vol 14 (5) ◽  
pp. 541-550 ◽  
Author(s):  
John C. Lisko ◽  
Vasilis C. Babaliaros ◽  
Jaffar M. Khan ◽  
Norihiko Kamioka ◽  
Patrick T. Gleason ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Mitral Annulus ◽  
Transcatheter Mitral Valve Replacement

Left ventricular remodeling after transcatheter mitral valve replacement with Tendyne

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Fukui ◽  
P Sorajja ◽  
M Goessl ◽  
R Bae ◽  
B Sun ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Ventricular Remodeling ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Reverse Remodeling ◽  
Functional Changes ◽  
Transcatheter Mitral Valve Replacement ◽  
Lv Mass

Abstract Background Data on changes in left atrial (LA) and left ventricular (LV) volumes after transcatheter mitral valve replacement (TMVR) are limited. Purpose This study sought to describe the anatomical and functional changes in left-sided cardiac chambers by computed tomography angiography (CTA) from baseline to 1-month after TMVR with Tendyne prosthesis. Methods We analyzed patients who underwent TMVR with Tendyne prosthesis (Abbott Structural, Menlo Park, CA) between 2015 and 2018. Changes in LV end-diastolic volume (LVEDV), ejection fraction (LVEF), mass (LV mass), LA volume and global longitudinal strain (GLS) were assessed at baseline and at 1-month after TMVR with CTA. Specific Tendyne implant characteristics were identified and correlated with remodeling changes. Results A total of 36 patients (mean age 73±8 years, 78% men, 86% secondary MR) were studied. There were significant decreases in LVEDV (268±68 vs. 240±66ml, p&lt;0.001), LVEF (38±10 vs. 32±11%, p&lt;0.001), LV mass (126±37 vs. 117±32g, p&lt;0.001), LA volume (181±74 vs. 174±70 ml, p=0.027) and GLS (−12.6±5.1 vs. −9.5±4.0%, p&lt;0.001) from baseline to 1-month follow-up. Favorable LVEDV reverse-remodeling occurred in the majority (30 of 36 patients, or 83%). Closer proximity of the Tendyne apical pad to the true apex was predictive of favorable remodeling (pad distance: 25.0±7.7 vs. 33.5±8.8mm, p=0.02 for those with and without favorable remodeling). Conclusions TMVR with Tendyne results in favorable left-sided chamber remodeling in the majority of patients treated, as detected on CTA at 1-month after implantation. CTA identifies the favorable post-TMVR changes, which could be related to specific characteristics of the device implantation. Funding Acknowledgement Type of funding source: None

scholarly journals Utility of 3-dimensional transoesophageal echocardiography for mitral annular sizing in transcatheter mitral valve replacement procedures: a cardiac computed tomography comparative study

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Coisne ◽  
F Pontana ◽  
S Aghezzaf ◽  
S Mouton ◽  
H Ridon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Mitral Valve ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Cardiac Computed Tomography ◽  
Transoesophageal Echocardiography ◽  
3 Dimensional ◽  
Ct Measurements ◽  
Good Ability ◽  
Transcatheter Mitral Valve Replacement

Abstract Funding Acknowledgements Type of funding sources: None. Background.  3-dimensional transoesophageal echocardiography (3D-TEE) is frequently used as an initial screening tool in the evaluation of patients who are candidates to Transcatheter Mitral Valve Replacement (TMVR). However, little is known about the imaging correlation with the gold-standard computed tomography (CT) imaging. We aimed at testing the quantitative differences between these two modalities and finding the best 3D-TEE parameters for TMVR screening. Methods. We included 57 patients referred to our Heart Valve Clinic for TMVR with prostheses specifically designed for the mitral valve. Mitral annulus (MA) analyses were performed using commercially available software in 3D-TEE and CT. Results. 3D-TEE was feasible in 52 patients (91%). Although 3D-TEE measurements were slightly lower than in CT, both measurements of projected MA area and perimeter showed excellent correlation with small differences between the two modalities (r = 0.88 and r = 0.92 respectively, p &lt; 0.0001). Correlations were significant but lower for MA diameters (r = 0.68 to 0.72, p &lt; 0.0001) and mitro-aortic angle (r = 0.53, p = 0.0001). ROC curve analyses showed that 3D-TEE had a good ability to predict TMVR screening success defined by constructors based on CT measurements with a range of 12.9 to 15cm² for MA area (AUC = 0.88-0.91, p &lt; 0.0001), 128 to 139mm for MA perimeter (AUC = 0.85-0.91, p &lt; 0.0001), 35 to 39mm for anteroposterior diameter (AUC = 0.79-0.84 p &lt; 0.0001) and 37 to 42mm for posteromedial-anterolateral diameter (AUC = 0.81-0.89, p &lt; 0.0001) (Figure 1). Conclusion. 3D-TEE measurements of MA dimensions display strong correlation with CT measurements in patients undergoing TMVR screening process. 3D-TEE should be proposed as a reasonable alternative to CT in this vulnerable population. Abstract Figure.

scholarly journals Mitral Annular Evaluation With CT in the Context of Transcatheter Mitral Valve Replacement

2015 ◽  
Vol 8 (5) ◽  
pp. 612-615 ◽  
Author(s):  
Philipp Blanke ◽  
Danny Dvir ◽  
Anson Cheung ◽  
Robert A. Levine ◽  
Christopher Thompson ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Transcatheter Mitral Valve Replacement
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