scholarly journals THE FORMATION OF MYELOMA PROTEIN BY A MOUSE PLASMA CELL TUMOR

1958 ◽  
Vol 108 (1) ◽  
pp. 121-130 ◽  
Author(s):  
Daniel Nathans ◽  
John L. Fahey ◽  
Michael Potter
Keyword(s):  
Intravenous Injection ◽  
Plasma Cell ◽  
Specific Activity ◽  
Cell Tumor ◽  
Activity Time ◽  
Myeloma Protein ◽  
Mouse Plasma ◽  
Plasma Cell Tumor ◽  
Myeloma Proteins

The origin of the myeloma protein found in mice bearing the plasma cell tumor X5563 has been investigated. Specific activity-time curves of the myeloma proteins isolated from the tumor and from the plasma of these animals were compared following intravenous injection of L-lysine-C14. The results indicate that myeloma protein is synthesized in the plasma cell tumor.

scholarly journals THE INTRACELLULAR DISTRIBUTION OF GAMMA GLOBULIN IN A MOUSE PLASMA CELL TUMOR (X5563) AS REVEALED BY FLUORESCENCE AND ELECTRON MICROSCOPY

1962 ◽  
Vol 116 (4) ◽  
pp. 423-432 ◽  
Author(s):  
Richard A. Rifkind ◽  
Elliott F. Osserman ◽  
Konrad C. Hsu ◽  
Councilman Morgan
Keyword(s):  
Endoplasmic Reticulum ◽  
Plasma Cell ◽  
Secretory Protein ◽  
Cell Tumor ◽  
Secretory Process ◽  
Cytoplasmic Matrix ◽  
Mouse Plasma ◽  
Plasma Cell Tumor ◽  
Antibody Staining ◽  
Fluorescence And Electron Microscopy

Ferritin- and fluorescein-conjugated antibody staining has been applied to a study of a mouse plasma cell tumor. The presence of myeloma globulin within cisternae of the endoplasmic reticulum was observed at a stage of the secretory process when the remainder of the cytoplasm was essentially free of labeled globulin. The distribution of ferritin suggested a functional heterogeneity among units of the endoplasmic reticulum. Apparently, progressive accumulation of globulin results in distension of the endoplasmic reticulum and, occasionally, in the appearance of considerable quantities of this secretory protein in the extracisternal cytoplasmic matrix. Participation of the Golgi apparatus in the packaging and release of small quantitites of globulin seems likely. In addition, however, fragmentation of the peripheral cytoplasm with rupture of distended ergastoplasmic vesicles appeared to be another pathway whereby globulin is secreted.

Mouse myeloma proteins with antihapten antibody activity. Protein produced by plasma cell tumor MOPC-315

Biochemistry ◽  
1968 ◽  
Vol 7 (11) ◽  
pp. 4126-4134 ◽  
Author(s):  
Herman N. Eisen ◽  
Ernest S. Simms ◽  
Michael. Potter
Keyword(s):  
Plasma Cell ◽  
Cell Tumor ◽  
Antibody Activity ◽  
Plasma Cell Tumor ◽  
Myeloma Proteins ◽  
Mouse Myeloma

Presence of RNA Methylases in Intracisternal A Particles Purified from a Mouse Plasma Cell Tumor

1980 ◽  
Vol 103 (2) ◽  
pp. 339-347 ◽  
Author(s):  
Ana Berta CHEPELINSKY ◽  
Raymond GANTT ◽  
Nelson WIVEL
Keyword(s):  
Plasma Cell ◽  
Cell Tumor ◽  
Mouse Plasma ◽  
Plasma Cell Tumor
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