scholarly journals Detection of active kallikrein in induced blister fluids of hereditary angioedema patients.

1980 ◽  
Vol 152 (3) ◽  
pp. 742-747 ◽  
Author(s):  
J G Curd ◽  
L J Prograis ◽  
C G Cochrane
Keyword(s):  
Molecular Weight ◽  
Smooth Muscle ◽  
High Molecular Weight ◽  
Hereditary Angioedema ◽  
C1 Inhibitor ◽  
High Molecular Weight Kininogen ◽  
Hageman Factor ◽  
Normal Volunteers

Six suction-induced blister fluids obtained from five patients with hereditary angioedema (HAE) contained active kallikrein, whereas only two blister fluids obtained from eight normal volunteers contained small amounts of this activity. Kallikrein was present in large amounts of HAE blister fluids as assessed by its ability to liberate smooth-muscle-contracting activity from purified high molecular weight kininogen. It was inhibited by purified antibodies specific for plasma prekallikrein and also by purified C1 inhibitor, but not by antibodies specific for C1s. These observations suggest that activation of the Hageman-factor-dependent pathways occurs in the tissues of HAE patients, and once generated, active kallikrein persists in these tissues.

scholarly journals Cleaved High Molecular Weight Kininogen Correlates With Hereditary Angioedema Due To C1-Inhibitor Deficiency

2019 ◽  
Vol 143 (2) ◽  
pp. AB42
Author(s):  
Adriana Moreno ◽  
Fernanda L. Nunes ◽  
Yunan C. Januario ◽  
Luana S.M. Maia ◽  
Mariana P.L. Ferriani ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Hereditary Angioedema ◽  
C1 Inhibitor ◽  
High Molecular Weight Kininogen ◽  
C1 Inhibitor Deficiency

The Contact Phase of Blood Coagulation in Diabetes Mellitus and in Patients with Vasculopathy

1984 ◽  
Vol 52 (03) ◽  
pp. 221-223 ◽  
Author(s):  
M Christe ◽  
P Gattlen ◽  
J Fritschi ◽  
B Lämmle ◽  
W Berger ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Molecular Weight ◽  
Blood Coagulation ◽  
High Molecular Weight ◽  
Negative Correlation ◽  
Factor Xii ◽  
C1 Inhibitor ◽  
High Molecular Weight Kininogen ◽  
Contact Phase ◽  
Α2 Macroglobulin

SummaryThe contact phase has been studied in diabetics and patients with macroangiopathy. Factor XII and high molecular weight kininogen (HMWK) are normal. C1-inhibitor and also α2-macroglobulin are significantly elevated in diabetics with complications, for α1-macroglobulin especially in patients with nephropathy, 137.5% ± 36.0 (p <0.001). C1-inhibitor is also increased in vasculopathy without diabetes 113.2 ± 22.1 (p <0.01).Prekallikrein (PK) is increased in all patients’ groups (Table 2) as compared to normals. PK is particularly high (134% ± 32) in 5 diabetics without macroangiopathy but with sensomotor neuropathy. This difference is remarkable because of the older age of diabetics and the negative correlation of PK with age in normals.

scholarly journals Hageman factor, high molecular weight kininogen, and prekallikrein in chronic liver disease.

1986 ◽  
Vol 39 (9) ◽  
pp. 1003-1005 ◽  
Author(s):  
C Cordova ◽  
F Violi ◽  
C Alessandri ◽  
D Ferro ◽  
M Saliola ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
High Molecular Weight ◽  
Chronic Liver ◽  
High Molecular Weight Kininogen ◽  
Hageman Factor

Prekallikrein, hageman factor, and high molecular weight kininogen in liver cirrhosis

1986 ◽  
Vol 41 ◽  
pp. 41
Author(s):  
C. Cordova ◽  
F. Violi ◽  
C. Alessandri ◽  
D. Ferro ◽  
M. Saliola ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Liver Cirrhosis ◽  
High Molecular Weight ◽  
High Molecular Weight Kininogen ◽  
Hageman Factor
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