Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu-2a antibodies.
1982 ◽
Vol 155
(5)
◽
pp. 1579-1584
◽
Keyword(s):
T Cell
◽
Out of a panel of seven monoclonal antibodies with affinity for human lymphoid cells, three were shown to prevent cytotoxic T cell activity, whereas none affected natural killer cell activity when applied without complement. Anti-OKT3 and anti-Leu-2a, with affinity for all T cells and the cytotoxic/suppressive subset, respectively were both shown to inhibit T killing by their interaction with the effector cell. For anti-OKT3, the inhibition remained after free antibody was washed away. Anti-Leu-2a, in contrast, induced a rapidly reversible inhibition. Using a single cell assay, anti-OKT3 was shown to reduce the lytic ability without affecting target cell binding, whereas anti-Leu-2a prevented the effectors from binding target cells.
1987 ◽
Vol 108
(2)
◽
pp. 313-322
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1993 ◽
Vol 161
(1)
◽
pp. 135-137
◽
Keyword(s):
1990 ◽
Vol 6
(7)
◽
pp. 905-918
◽
Keyword(s):
1997 ◽
Vol 84
(3_suppl)
◽
pp. 1296-1298
◽
1986 ◽
Vol 92
(1)
◽
pp. 117-123
◽
Keyword(s):
1986 ◽
Vol 86
(2)
◽
pp. 225-229
◽
Keyword(s):
1982 ◽
Vol 10
(01n04)
◽
pp. 44-54
◽
1990 ◽
Vol 26
(2)
◽
pp. 157-170
◽
Keyword(s):
1983 ◽
Vol 28
(3)
◽
pp. 361-370
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