scholarly journals Frequency and Phenotyping of Human Immunodeficiency Virus (HIV)–Specific CD8+T Cells in HIV‐Infected Children, Using Major Histocompatibility Complex Class I Peptide Tetramers

2001 ◽  
Vol 183 (11) ◽  
pp. 1565-1573 ◽  
Author(s):  
Daniel Scott‐Algara ◽  
Florence Buseyne ◽  
Stephane Blanche ◽  
Christine Rouzioux ◽  
C. Jouanne ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Cd8 T Cells ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Immunodeficiency Virus

scholarly journals Human Immunodeficiency Virus Nef Induces Rapid Internalization of the T-Cell Coreceptor CD8αβ

2005 ◽  
Vol 79 (17) ◽  
pp. 11422-11433 ◽  
Author(s):  
Veronique Stove ◽  
Inge Van de Walle ◽  
Evelien Naessens ◽  
Elisabeth Coene ◽  
Christophe Stove ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Surface Expression ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Immunodeficiency Virus ◽  
Β Chain

ABSTRACT Human immunodeficiency virus (HIV) Nef is a membrane-associated protein decreasing surface expression of CD4, CD28, and major histocompatibility complex class I on infected cells. We report that Nef strongly down-modulates surface expression of the β-chain of the CD8αβ receptor by accelerated endocytosis, while CD8 α-chain expression is less affected. By mutational analysis of the cytoplasmic tail of the CD8 β-chain, an FMK amino acid motif was shown to be critical for Nef-induced endocytosis. Although independent of CD4, endocytosis of the CD8 β-chain was abrogated by the same mutations in Nef that affect CD4 down-regulation, suggesting common molecular interactions. The ability to down-regulate the human CD8 β-chain was conserved in HIV-1, HIV-2, and simian immunodeficiency virus SIVmac239 Nef and required an intact AP-2 complex. The Nef-mediated internalization of receptors, such as CD4, major histocompatibility complex class I, CD28, and CD8αβ, may contribute to the subversion of the host immune system and progression towards AIDS.

CROSS-REACTIVITY OF CYTOMEGALOVIRUS-SPECIFIC CD8+ T CELLS TO ALLO-MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I MOLECULES

2004 ◽  
Vol 77 (12) ◽  
pp. 1879-1885 ◽  
Author(s):  
Laila E. Gamadia ◽  
Ester B. Remmerswaal ◽  
Sugianto Surachno ◽  
Neubury M. Lardy ◽  
Pauline M. Wertheim-van Dillen ◽  
...  
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Cd8 T Cells ◽  
Cross Reactivity ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex
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