scholarly journals Modelling chronic hepatitis B using the Marchuk-Petrov model

2021 ◽  
Vol 2099 (1) ◽  
pp. 012036
Author(s):  
M Yu Khristichenko ◽  
Yu M Nechepurenko ◽  
D S Grebennikov ◽  
G A Bocharov
Keyword(s):  
Time Delay ◽  
Hepatitis B ◽  
Immune Responses ◽  
Periodic Solutions ◽  
Delay Differential Equations ◽  
Delay Systems ◽  
Time Delay Systems ◽  
Stable Periodic ◽  
Delay Differential ◽  
Parameter Values

Abstract Systems of time-delay differential equations are widely used to study the dynamics of infectious diseases and immune responses. The Marchuk-Petrov model is one of them. Stable non-trivial steady states and stable periodic solutions to this model can be interpreted as chronic viral diseases. In this work we briefly describe our technology developed for computing steady and periodic solutions of time-delay systems and present and discuss the results of computing periodic solutions for the Marchuk-Petrov model with parameter values corresponding to the hepatitis B infection.

scholarly journals Periodic Solutions of a System of Delay Differential Equations for a Small Delay

2002 ◽  
Vol 7 (2) ◽  
pp. 295
Author(s):  
Adu A.M. Wasike ◽  
Wandera Ogana
Keyword(s):  
Periodic Solution ◽  
Differential Equations ◽  
Periodic Solutions ◽  
Delay Differential Equations ◽  
Original System ◽  
System Of Equations ◽  
Asymptotically Stable ◽  
Stable Periodic Solution ◽  
Stable Periodic ◽  
Delay Differential

We prove the existence of an asymptotically stable periodic solution of a system of delay differential equations with a small time delay t > 0. To achieve this, we transform the system of equations into a system of perturbed ordinary differential equations and then use perturbation results to show the existence of an asymptotically stable periodic solution. This approach is contingent on the fact that the system of equations with t = 0 has a stable limit cycle. We also provide a comparative study of the solutions of the original system and the perturbed system.  This comparison lays the ground for proving the existence of periodic solutions of the original system by Schauder's fixed point theorem.   

scholarly journals Infinitely Many Periodic Solutions to Delay Differential Equations via Critical Point Theory

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Xiaosheng Zhang ◽  
Duo Wang
Keyword(s):  
Time Delay ◽  
Differential Equations ◽  
Critical Point ◽  
Periodic Solutions ◽  
Critical Point Theory ◽  
Delay Differential Equations ◽  
Point Theory ◽  
Delay Differential ◽  
Infinitely Many Periodic Solutions

By the critical point theory, infinitely many 4σ-periodic solutions are obtained for the system of delay differential equationsẋt=-f(x(t-σ)), whereσ∈(0,+∞)andf∈C(ℝn,ℝn). It is shown that all the periodic solutions derived here are brought about by the time delay.

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