scholarly journals ComprehensiveBench: a Benchmark for the Extensive Evaluation of Global Scheduling Algorithms

2015 ◽  
Vol 649 ◽  
pp. 012007 ◽  
Author(s):  
Laércio L Pilla ◽  
Tiago C Bozzetti ◽  
Márcio Castro ◽  
Philippe O A Navaux ◽  
Jean-François Méhaut
2018 ◽  
Vol 97 ◽  
pp. 83-98 ◽  
Author(s):  
Amina Magdich ◽  
Yessine Hadj Kacem ◽  
Mickaël Kerboeuf ◽  
Adel Mahfoudhi ◽  
Mohamed Abid

2014 ◽  
Vol E97.B (7) ◽  
pp. 1474-1482 ◽  
Author(s):  
Takayoshi IWATA ◽  
Hiroyuki MIYAZAKI ◽  
Fumiyuki ADACHI

2020 ◽  
Author(s):  
Carrow Wells ◽  
David Drewry ◽  
Julie E. Pickett ◽  
Alison D. Axtman

Building upon a wealth of published knowledge surrounding the pyrazolopyrimidine scaffold, we designed a small library around the most selective small molecule CK2 inhibitors reported. Through extensive evaluation of this library we identified inhibitor 24 (SGC-CK2-1) as a potent, selective, and cell-active CK2 chemical probe. Remarkably, despite years of research pointing to CK2 as a key driver in cancer, our probe did not elicit an antiproliferative phenotype in cell lines tested. While many publications have attempted tocharacterize CK2 function, CK2 biology is complex and a high-quality chemical tool like SGC-CK2-1 will aid in connecting CK2 functions to phenotypes.


Sign in / Sign up

Export Citation Format

Share Document