Amelioration of Alpha-1 Antitrypsin Deficiency Diseases with Genome Editing in Transgenic Mice

2018 ◽  
Vol 29 (8) ◽  
pp. 861-873 ◽  
Author(s):  
Shen Shen ◽  
Minerva E. Sanchez ◽  
Keith Blomenkamp ◽  
Erik M. Corcoran ◽  
Eugenio Marco ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Genome Editing ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin ◽  
Deficiency Diseases

An electronic nose distinguishes the exhaled breath condensates of alpha-1-antitrypsin deficiency patients and healthy controls

Pneumologie ◽  
2009 ◽  
Vol 63 (S 01) ◽  
Author(s):  
AR Koczulla ◽  
A Hattesohl ◽  
S Noeske ◽  
C Vogelmeier ◽  
R Bals
Keyword(s):  
Electronic Nose ◽  
Exhaled Breath ◽  
Healthy Controls ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin

Characterization of the Serum a1-Antitripsine Level in Primary Spontaneous Pneumotorax Patients

2018 ◽  
Vol 69 (9) ◽  
pp. 2591-2593
Author(s):  
Cristina Grigorescu ◽  
Liviu Ciprian Gavril ◽  
Laura Gavril ◽  
Tiberiu Lunguleac ◽  
Bogdan Mihnea Ciuntu ◽  
...  
Keyword(s):  
Serum Level ◽  
Pulmonary Emphysema ◽  
Spontaneous Pneumothorax ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin ◽  
Determining Factor

Diagnosis of primary or idiopathic spontaneous pneumothorax is one of exclusion, and in fact defines an entity that may have a difficult or impossible cause to be highlighted by current means, we consider it appropriate to study these etiopathogenic aspects. There is a definite association between alpha-1 antitrypsin deficiency and pulmonary emphysema and indirect spontaneous pneumothorax secondary to an emphysematous pulmonary lesion. Dose of alpha-1 antitrypsin is an immunoturbinimetric method for in vitro determination of alpha-1 antitrypsin in human serum and plasma. This product is calibrated to be used for the Daytona RX analyzer. The serum level of alpha-1-antitrypsin is not a determining factor in the postoperative evolution characterized by the interval until air loss disappears, but certainly exerts some influence, the exact level of which remains to be determined.

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