Aerosol Delivery During Mechanical Ventilation: A Predictive In-Vitro Lung Model

1992 ◽  
Vol 5 (4) ◽  
pp. 251-259 ◽  
Author(s):  
H.D. FULLER ◽  
M.B. DOLOVICH ◽  
C. CHAMBERS ◽  
M.T. NEWHOUSE
Keyword(s):  
Mechanical Ventilation ◽  
Lung Model ◽  
Aerosol Delivery

scholarly journals Accurate Measurement of Functional Residual Capacity and Oxygen Consumption of Patients on Mechanical Ventilation

1983 ◽  
Vol 11 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Kevin R. Cooper ◽  
Peter A. Boswell
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Oxygen Consumption ◽  
Functional Residual Capacity ◽  
Lung Model ◽  
Capacity Measurement ◽  
Icu Patients ◽  
Residual Capacity

We developed an apparatus and technique for the simultaneous measurement of functional residual capacity and oxygen uptake (V̇O2) for use in intensive care unit (ICU) patients. The accuracy of the functional residual capacity measurement was proven using an in vitro lung model and the reproducibility of this measurement was established by use in ICU patients. We tested the accuracy of the V̇O2 measurement in comparison with two other methods in common use among ICU patients and our method proved accurate. We conclude that this technique for measurement of functional residual capacity and V̇O2 is highly accurate and easily applied to patients on any mode of mechanical ventilation.

Therapeutic Aerosol Delivery during Mechanical Ventilation

1996 ◽  
Vol 30 (6) ◽  
pp. 644-655 ◽  
Author(s):  
Denise M Coleman ◽  
H William Kelly ◽  
Bennie C Mcwilliams ◽  
Annette Pérez ◽  
Marc M Perreault
Keyword(s):  
Mechanical Ventilation ◽  
Case Reports ◽  
Data Extraction ◽  
Case Series ◽  
Aerosol Delivery ◽  
Delivery Device ◽  
Unique Challenge ◽  
Medline Search

Objective To provide an overview of aerosol drug delivery during mechanical ventilation in the pediatric and adult populations. Data Sources Published articles and abstracts identified in a MEDLINE search (1984–July 1994) were reviewed. Study Selection All articles and abstracts found, including review articles, in vivo and in vitro studies, case reports, and case series pertaining to issues involving aerosol delivery during mechanical ventilation, were reviewed. No predetermined selection criteria were used to exclude studies. Data Extraction Percent delivery of the starting dose to either the patients or the various in vitro lung models, as well as each variable possibly affecting delivery for each study, were tabulated for each study reviewed. Data Synthesis The delivery of therapeutic aerosols to endotracheally intubated and mechanically ventilated patients presents a unique challenge for healthcare providers. Delivery can be affected by the diameter of the endotracheal tube and ventilator circuitry, type of ventilator, ventilator modes, type of delivery device, and how the delivery device is operated and introduced into the ventilator circuitry. The drug being aerosolized may behave differently from one delivery system to another. The proper operation of each device requires attention to positioning in the ventilator circuit as well as the mode of ventilation. Conclusions No apparent advantage exists for metered-dose inhalers with a large-volume adapter over jet nebulizers, as each method of delivery is capable of similar efficiency (5–15%). Sufficient attention to detail, including the use of an efficient nebulizer and/or adapter and proper placement and operating method, is required to provide optimal delivery. For bronchodilator administration, careful monitoring of outcomes will provide the most optimal dosing schedule.

In Vitro Performance of Spacers for Aerosol Delivery during Adult Mechanical Ventilation

2015 ◽  
Vol 28 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Nabile Boukhettala ◽  
Thierry Porée ◽  
Patrice Diot ◽  
Laurent Vecellio
Keyword(s):  
Mechanical Ventilation ◽  
Aerosol Delivery ◽  
In Vitro Performance

scholarly journals Effect of Nebulizer Designs on Aerosol Delivery During Non-Invasive Mechanical Ventilation: A Modeling Study of In Vitro Data

2017 ◽  
Vol 3 (1) ◽  
pp. 233-241 ◽  
Author(s):  
Haitham Saeed ◽  
Ahmed A. Elberry ◽  
Abeer Salah Eldin ◽  
Hoda Rabea ◽  
Mohamed E. A. Abdelrahim
Keyword(s):  
Mechanical Ventilation ◽  
Invasive Mechanical Ventilation ◽  
Aerosol Delivery ◽  
Non Invasive ◽  
Vitro Data ◽  
In Vitro Data ◽  
Modeling Study

In vitro evaluation of aerosol delivery of aztreonam lysine (AZLI): an adult mechanical ventilation model

2017 ◽  
Vol 14 (12) ◽  
pp. 1447-1453 ◽  
Author(s):  
Alejandro Rodríguez ◽  
María Cabrera ◽  
Luis F. Reyes ◽  
María Bodí ◽  
Sandra Trefler ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Aerosol Delivery ◽  
In Vitro Evaluation

In vitro study and semiempirical model for aerosol delivery control during mechanical ventilation

2005 ◽  
Vol 31 (6) ◽  
pp. 871-876 ◽  
Author(s):  
Laurent Vecellio ◽  
Claude Guérin ◽  
Daniel Grimbert ◽  
Michele De Monte ◽  
Patrice Diot
Keyword(s):  
Mechanical Ventilation ◽  
In Vitro Study ◽  
Vitro Study ◽  
Semiempirical Model ◽  
Aerosol Delivery
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