The Effects of Sex Differences and Hormonal Contraception on Outcomes after Collegiate Sports-Related Concussion

2018 ◽  
Vol 35 (11) ◽  
pp. 1242-1247 ◽  
Author(s):  
Virginia Gallagher ◽  
Natalie Kramer ◽  
Kristin Abbott ◽  
John Alexander ◽  
Hans Breiter ◽  
...  
Keyword(s):  
Sex Differences ◽  
Hormonal Contraception ◽  
Collegiate Sports

scholarly journals Clinical Recovery Timelines following Sport-Related Concussion in Men's and Women's Collegiate Sports

2021 ◽  
Author(s):  
Abigail C. Bretzin ◽  
Carrie Esopenko ◽  
Bernadette A. D'Alonzo ◽  
Douglas J. Wiebe
Keyword(s):  
Sex Differences ◽  
Median Time ◽  
Female Athletes ◽  
Symptom Duration ◽  
Athletic Activity ◽  
Collegiate Sports ◽  
Ivy League ◽  
Big Ten ◽  
Symptom Resolution ◽  
Full Activity

Abstract Context: Past work has identified sex differences in sport-related concussion (SRC) incidence and recovery time; however, few have examined sex differences in specific recovery trajectories: time to symptom resolution, return-to-academics, and return-to-athletic activity across collegiate sports. Objective: To examine sex differences in SRC recovery trajectories across a number of varsity sports with differing levels of contact. Design: Descriptive Epidemiology Study. Setting: College varsity and club sports. Patients or Other Participants: SRCs sustained by student-athletes (N=1,974; 38.7% female) participating in Ivy League sports were tracked from 2013/14-2018/19. Intervention(s): Athletic trainers collected concussive injury and recovery characteristics as part of the Ivy League-Big Ten Epidemiology of Concussion Study's surveillance system. Main Outcome Measure(s): Time to symptom resolution, return-to-academics, and return-to-limited and full athletic activity were collected. Survival analyses determined time from injury to each recovery outcome for males and females by sport. Peto tests compared recovery outcomes between males and female athletes and by sport. Results: The median time to symptom resolution overall was 9 days [IQR:4,18], return-to-academics was 8 days [IQR:3,15], return-to-limited activity was 12 days [IQR:8,23], and return-to-full activity was 16 days [IQR:10,29]. There were significant differences overall between sexes for median time to symptom resolution (males: 8 days [IQR:4,17], females: 9 days [IQR:5,20], p=0.029) and return-to-academics (males: 7 days [IQR:3,14], females: 9 days [IQR:4,17], p<.001), but not return to athletics (limited activity, p=0.107; full activity, p=0.578). Within-sport comparisons found that female lacrosse athletes had longer symptom resolution (p=0.030) and return to academics (p=0.035) compared to males, while male volleyball athletes took longer to return to limited (p=0.020) and full (p=0.049) athletic activity compared to females. Conclusion: There were significant differences in recovery timelines between sexes. Females experienced longer symptom duration and time to return-to-academics compared to male athletes, but females and males presented similar timelines for return-to-athletics.

scholarly journals Sex-Related Differences in Drugs with Anti-Inflammatory Properties

2021 ◽  
Vol 10 (7) ◽  
pp. 1441
Author(s):  
André Farkouh ◽  
Christoph Baumgärtel ◽  
Roman Gottardi ◽  
Margit Hemetsberger ◽  
Martin Czejka ◽  
...  
Keyword(s):  
Sex Differences ◽  
Hormonal Contraception ◽  
Future Research ◽  
Routine Practice ◽  
Sex And Gender ◽  
Event Monitoring ◽  
Cox Inhibitors ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
And Gender

There is increasing evidence of sex differences in the action of anti-inflammatory drugs, with women being at significantly higher risk of adverse effects. Nevertheless, clinicians’ awareness of the implications of these sex differences on dosing and adverse event monitoring in routine practice is still in need of improvement. We reviewed the literature evaluating sex differences in terms of pharmacokinetics and pharmacodynamics of anti-inflammatory drugs. The anti-thrombotic activity of selective and non-selective COX-inhibitors tends to be stronger in men than women. Side effect profiles differ with regards to gastro-intestinal, renal and hepatic complications. Glucocorticosteroids were found to be more effective in men; women were more sensitive to corticosteroids when their oestradiol levels were high, a finding important for women taking hormonal contraception. TNF-alpha inhibitors have a longer half-life in men, leading to stronger immunosuppression and this a higher incidence of infections as side effects. Although research on sex differences in the effectiveness and safety of drugs is increasing, findings are often anecdotal and controversial. There is no systematic sex-differentiated reporting from clinical trials, and women are often under-represented. As personalized medicine is gaining in importance, sex, and gender aspects need to become integral parts of future research and policy making.

Author response for "Sex differences in the brains of capuchin monkeys ( Sapajus [Cebus] apella )"

2020 ◽  
Author(s):  
Erin E. Hecht ◽  
Olivia T. Reilly ◽  
Marcela Benítez ◽  
Kimberley A. Phillips ◽  
Sarah Brosnan
Keyword(s):  
Sex Differences ◽  
Cebus Apella ◽  
Author Response ◽  
Capuchin Monkeys

Auditory Perception of Rhyming in Kindergarten Children

1973 ◽  
Vol 16 (3) ◽  
pp. 482-487 ◽  
Author(s):  
June D. Knafle
Keyword(s):  
Sex Differences ◽  
Auditory Perception ◽  
Kindergarten Children ◽  
Different Types ◽  
Consonant Sounds

One hundred and eighty-nine kindergarten children were given a CVCC rhyming test which included four slightly different types of auditory differentiation. They obtained a greater number of correct scores on categories that provided maximum contrasts of final consonant sounds than they did on categories that provided less than maximum contrasts of final consonant sounds. For both sexes, significant differences were found between the categories; although the sex differences were not significant, girls made more correct rhyming responses than boys on the most difficult category.

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