Human Flexor Tendon Tissue Engineering: Decellularization of Human Flexor Tendons Reduces Immunogenicity In Vivo

2012 ◽  
Vol 18 (7-8) ◽  
pp. 796-805 ◽  
Author(s):  
Shyam S. Raghavan ◽  
Colin Y.L. Woon ◽  
Armin Kraus ◽  
Kai Megerle ◽  
Matthew S.S. Choi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Flexor Tendon ◽  
Tendon Tissue ◽  
Flexor Tendons ◽  
Tendon Tissue Engineering

Flexor Tendon Tissue Engineering: Acellularization of Human Flexor Tendons with Preservation of Biomechanical Properties and Biocompatibility

2011 ◽  
Vol 17 (8) ◽  
pp. 819-828 ◽  
Author(s):  
Brian C. Pridgen ◽  
Colin Y.L. Woon ◽  
Maxwell Kim ◽  
Johan Thorfinn ◽  
Derek Lindsey ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Flexor Tendon ◽  
Biomechanical Properties ◽  
Tendon Tissue ◽  
Flexor Tendons ◽  
Tendon Tissue Engineering

Flexor Tendon Tissue Engineering: A Comparison of Tenocytes Versus Stem Cells

2005 ◽  
Vol 116 (Supplement) ◽  
pp. 76-77
Author(s):  
Gil S. Kryger ◽  
Hung Pham ◽  
Steven J. Bates ◽  
Cindy Wu ◽  
James Chang
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Flexor Tendon ◽  
Tendon Tissue ◽  
Tendon Tissue Engineering

A Poly(lactic-co-glycolic acid) Knitted Scaffold for Tendon Tissue Engineering: An In Vitro and In Vivo Study

2010 ◽  
Vol 21 (13) ◽  
pp. 1737-1760 ◽  
Author(s):  
Cédryck Vaquette ◽  
Saïd Slimani ◽  
Cyril J. F. Kahn ◽  
Nguyen Tran ◽  
Rachid Rahouadj ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Glycolic Acid ◽  
In Vivo Study ◽  
Tendon Tissue ◽  
Tendon Tissue Engineering

Optimization of Flexor Tendon Tissue Engineering With a Cyclic Strain Bioreactor

2008 ◽  
Vol 33 (8) ◽  
pp. 1388-1396 ◽  
Author(s):  
Jonathan Riboh ◽  
Alphonsus K.S. Chong ◽  
Hung Pham ◽  
Michael Longaker ◽  
Christopher Jacobs ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Flexor Tendon ◽  
Cyclic Strain ◽  
Tendon Tissue ◽  
Tendon Tissue Engineering

scholarly journals Anisotropic cytocompatible electrospun scaffold for tendon tissue engineering elicits limited inflammatory response in vitro

2018 ◽  
Vol 33 (1) ◽  
pp. 127-139 ◽  
Author(s):  
Andrea Fotticchia ◽  
David Musson ◽  
Cristina Lenardi ◽  
Emrah Demirci ◽  
Yang Liu
Keyword(s):  
Tissue Engineering ◽  
Inflammatory Response ◽  
Social Impact ◽  
Polymer Processing ◽  
High Recurrence Rate ◽  
Tendon Tissue ◽  
Tendon Tissue Engineering ◽  
Tendon Tears

Tendon tears are a relevant concern for today’s national health systems because of their social impact and high recurrence rate. The current gold standard for fixing tendon tears is surgical repair; however, this strategy is not able to fully re-establish tendon integrity and functionality. Tissue engineering approaches aim at promoting tissue regeneration by delivering the opportune signals to the injured site combining biomaterials, cells and biochemical cues. Electrospinning is currently one of the most versatile polymer processing techniques that allows manufacturing of nano- and micro-fibres substrates. Such fibrous morphology is deemed to be an ideal substrate to convey topographical cues to cells. Here we evaluated the potential of polycaprolactone processed by means of electrospinning technology for tendon tissue engineering. Fibrous free-of-defects substrate with random and aligned fibres were successfully fabricated. Rat tenocytes were used to assess the cytocompatibility of the substrates for application as tendon tissue engineered devices. Tenocytes were able to proliferate and adapt to the substrates topography acquiring an elongated morphology, which is the precondition for oriented collagen deposition, when seeded on aligned fibres. Real time Polymerase Chain Reaction (Rt-PCR) also revealed the overall maintenance of tenocyte phenotype over 7 days culture. To verify suitability for in vivo implantation, the level of inflammatory cytokine genes expressed by THP-1 cells cultured in presence of electrospun polycaprolactone substrates was evaluated. Inflammatory response was limited. The novel preliminary in vitro work presented herein showing tenocytes compatibility and limited inflammatory cytokines synthesis suggests that electrospun polycaprolactone may be taken into consideration as substrate for tendon healing applications.

Flexor tendon tissue engineering: a comparison of tenocytes versus stem cells

2005 ◽  
Vol 201 (3) ◽  
pp. S45-S46 ◽  
Author(s):  
Giliel S. Kryger ◽  
Hung Pham ◽  
Cindy Wu ◽  
Steven Bates ◽  
James Chang
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Flexor Tendon ◽  
Tendon Tissue ◽  
Tendon Tissue Engineering

A Comparison of Tenocytes and Mesenchymal Stem Cells for Use in Flexor Tendon Tissue Engineering

2007 ◽  
Vol 32 (5) ◽  
pp. 597-605 ◽  
Author(s):  
Gil S. Kryger ◽  
Alphonsus K.S. Chong ◽  
Melinda Costa ◽  
Hung Pham ◽  
Steven J. Bates ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Flexor Tendon ◽  
Tendon Tissue ◽  
Tendon Tissue Engineering

Human Flexor Tendon Tissue Engineering

2013 ◽  
Vol 132 (4) ◽  
pp. 567e-576e ◽  
Author(s):  
Taliah Schmitt ◽  
Paige M. Fox ◽  
Colin Y. Woon ◽  
Simon J. Farnebo ◽  
Joel A. Bronstein ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Flexor Tendon ◽  
Tendon Tissue ◽  
Tendon Tissue Engineering

Human Flexor Tendon Tissue Engineering: Revitalization of Biostatic Allograft Scaffolds

2012 ◽  
Vol 18 (23-24) ◽  
pp. 2406-2417 ◽  
Author(s):  
Colin Y.L. Woon ◽  
Simon Farnebo ◽  
Taliah Schmitt ◽  
Armin Kraus ◽  
Kai Megerle ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Flexor Tendon ◽  
Tendon Tissue ◽  
Tendon Tissue Engineering
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