Cloning of the Human Sodium-Iodide Symporter Promoter and Characterization in a Differentiated Human Thyroid Cell Line, KAT-50

Thyroid ◽  
1998 ◽  
Vol 8 (1) ◽  
pp. 63-69 ◽  
Author(s):  
GOPALAKRISHNAN M. VENKATARAMAN ◽  
MUSTAFA YATIN ◽  
KENNETH B. AIN
2017 ◽  
Vol 14 (1) ◽  
pp. 53-68 ◽  
Author(s):  
BYOUNG-AE KIM ◽  
HYEON-GUN JEE ◽  
JIN WOOK YI ◽  
SU-JIN KIM ◽  
YOUNG JUN CHAI ◽  
...  

Apmis ◽  
1993 ◽  
Vol 101 (7-12) ◽  
pp. 767-776 ◽  
Author(s):  
GRO O. NESS ◽  
REIN AASLAND ◽  
JOHAN R. LILLEHAUG

Thyroid ◽  
2007 ◽  
Vol 17 (6) ◽  
pp. 497-509 ◽  
Author(s):  
Carla Espadinha ◽  
Branca Maria Cavaco ◽  
Valeriano Leite

Endocrinology ◽  
2003 ◽  
Vol 144 (1) ◽  
pp. 247-252 ◽  
Author(s):  
J. Van Sande ◽  
C. Massart ◽  
R. Beauwens ◽  
A. Schoutens ◽  
S. Costagliola ◽  
...  

Abstract The iodide transporter of the thyroid (NIS) has been cloned by the group of Carrasco. The NIS-mediated transport was studied by electrophysiological methods in NIS-expressing Xenopus oocytes. Using this method, the anion selectivity of NIS was different from that previously reported for thyroid cells, whereas perchlorate and perrhenate were found not transported. In this study we compared the properties of human NIS, stably transfected in COS-7 cells to those of the transport in a thyroid cell line, the FRTL5 cells, by measuring the transport directly. We measured the uptake of 125I−, 186ReO4−, and 99mTcO4− and studied the effect on it of known competing anions, i.e. ClO4−, SCN−, ClO3−, ReO4−, and Br−. We conclude that the properties of the NIS transporter account by themselves for the properties of the thyroid iodide transporter as described previously in thyroid slices. The order of affinity was: ClO4− > ReO4− > I− ≥ SCN− > ClO3− > Br−. NIS is also inhibited by dysidenin (as in dog thyroid).


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