Hypothyroidism Increases Cholesterol Gallstone Prevalence in Mice by Elevated Hydrophobicity of Primary Bile Acids

Thyroid ◽  
2021 ◽  
Author(s):  
Irina Kube ◽  
Luca Bartolomeo Tardio ◽  
Ute Hofmann ◽  
Ahmed Ghallab ◽  
Jan G. Hengstler ◽  
...  
Keyword(s):  
Bile Acids ◽  
Cholesterol Gallstone

scholarly journals Astragalus Polysaccharides Ameliorate Diet-Induced Gallstone Formation by Modulating Synthesis of Bile Acids and the Gut Microbiota

2021 ◽  
Vol 12 ◽  
Author(s):  
Qian Zhuang ◽  
Xin Ye ◽  
Shuang Shen ◽  
Jinnian Cheng ◽  
Yan Shi ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Bile Acids ◽  
Enterohepatic Circulation ◽  
Cholesterol Gallstone ◽  
Saturation Index ◽  
Quantitative Polymerase Chain Reaction ◽  
Gallbladder Bile ◽  
Farnesoid X Receptor ◽  
Chow Diet ◽  
Hydrophobicity Index

Cholesterol gallstone (CG) disease has relationships with several metabolic abnormalities. Astragalus polysaccharides (APS) have been shown to have multiple benefits against metabolic disorders. We attempted to uncover the effect and mechanism of action of APS on diet-induced CG formation in mice. Animals were fed a chow diet or lithogenic diet (LD) with or without APS supplementation. The effect of APS on CG formation was evaluated. The level of individual bile acids (BAs) in gallbladder bile and ileum were measured by liquid chromatography-tandem mass spectrometry. Real-time reverse transcription-quantitative polymerase chain reaction and western blotting were used to assess expression of the genes involved in BA metabolism and the enterohepatic circulation. Cecal contents were collected to characterize microbiota profiles. APS ameliorated LD-induced CG formation in mice. APS reduced the level of total cholesterol, bile acid hydrophobicity index and cholesterol saturation index in gallbladder bile. The protective effect of APS might result from reduced absorption of cholic acid in the intestine and increased hepatic BA synthesis. APS relieved the LD-induced activation of the intestinal farnesoid X receptor and decreased ileal expression of fibroblast growth factor 15. In the liver, expression of cytochrome P450 (Cyp) enzyme Cyp7a1 and Cyp7b1 was increased, whereas expression of adenosine triphosphate-binding cassette (Abc) transporters Abcg5 and Abcg8 was decreased by APS. APS improved the diversity of the gut microbiota and increased the relative abundance of the Bacteroidetes phylum. APS had demonstratable benefits against CG disease, which might be associated with enhanced BA synthesis and improved gut microbiota. Our results suggest that APS may be a potential strategy for the prevention of CG disease.

Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone

2020 ◽  
Vol 319 (3) ◽  
pp. G303-G308
Author(s):  
Jingli Cai ◽  
Zhaowen Wang ◽  
Guiming Chen ◽  
Dapeng Li ◽  
Jun Liu ◽  
...  
Keyword(s):  
Bile Acids ◽  
Cholesterol Gallstone ◽  
Organic Anion ◽  
Farnesoid X Receptor ◽  
Organic Anion Transporter ◽  
Anion Transporter ◽  
First Time ◽  
Main Factor

For the first time, our results indicate that the axis of farnesoid X receptor-organic anion transporter polypeptide 1A2 that physiologically regulates the reabsorption of bile acids might play an important role in the regulation of the composition of bile acids and make contribution to the development of cholelithiasis.

Bile acids substituted in the 6 position prevent cholesterol gallstone formation in the hamster

1990 ◽  
Vol 98 (2) ◽  
pp. 397-405 ◽  
Author(s):  
Bertram I. Cohen ◽  
Naoyuki Matoba ◽  
Erwin H. Mosbach ◽  
Nariman Ayyad ◽  
Khalida Hakam ◽  
...  
Keyword(s):  
Bile Acids ◽  
Cholesterol Gallstone ◽  
Gallstone Formation

scholarly journals (5) The Kinetic Study of Bile Acids in Patients with Cholesterol Gallstone

1978 ◽  
Vol 17 (1) ◽  
pp. 63-65
Author(s):  
Yoshio HATTA ◽  
Hirobumi SAITO ◽  
Michiyuki SHIMIZU
Keyword(s):  
Kinetic Study ◽  
Bile Acids ◽  
Cholesterol Gallstone

scholarly journals Bile acids in serum and bile of patients with cholesterol gallstone

1998 ◽  
Vol 4 (1) ◽  
pp. 82 ◽  
Author(s):  
Tian-Quan Han
Keyword(s):  
Bile Acids ◽  
Cholesterol Gallstone

Portal venous bile acids in cholesterol gallstone disease: Effect of treatment with chenodeoxycholic and cholic acids

Hepatology ◽  
1985 ◽  
Vol 5 (4) ◽  
pp. 661-665 ◽  
Author(s):  
Kurt Einarsson ◽  
Jon Ahlberg ◽  
Bo Angelin ◽  
Ingemar Björkhem ◽  
Staffan Ewerth
Keyword(s):  
Bile Acids ◽  
Cholesterol Gallstone ◽  
Gallstone Disease ◽  
Cholic Acids ◽  
Effect Of Treatment ◽  
Disease Effect

Bile acids, cholesterol, gallstone calcification, and the enterohepatic circulation of bilirubin

1999 ◽  
Vol 116 (5) ◽  
pp. 1276-1277 ◽  
Author(s):  
Alan F. Hofmann
Keyword(s):  
Bile Acids ◽  
Enterohepatic Circulation ◽  
Cholesterol Gallstone
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