Anatomical Distribution of Myeloid-Derived Suppressor Cells During HIV Infection

2021 ◽  
Author(s):  
Mahmoud Mohammad Yaseen ◽  
Nizar Mohammad Abuharfeil ◽  
Homa Darmani
Keyword(s):  
Hiv Infection ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Anatomical Distribution

scholarly journals Myeloid-derived suppressor cells and the pathogenesis of human immunodeficiency virus infection

Open Biology ◽  
2021 ◽  
Vol 11 (11) ◽  
Author(s):  
Mahmoud Mohammad Yaseen ◽  
Nizar Mohammad Abuharfeil ◽  
Homa Darmani
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Hiv Infection ◽  
Immune Activation ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Chronic Immune Activation ◽  
Immune Suppressor Cells ◽  
Immunodeficiency Virus ◽  
Immune Suppressor

There are several mechanisms by which human immunodeficiency virus (HIV) can mediate immune dysfunction and exhaustion during the course of infection. Chronic immune activation, after HIV infection, seems to be a key driving force of such unwanted consequences, which in turn worsens the pathological status. In such cases, the immune system is programmed to initiate responses that counteract unwanted immune activation, for example through the expansion of myeloid-derived suppressor cells (MDSCs). Although the expansion of immune suppressor cells in the setting of systemic chronic immune activation, in theory, is expected to contain immune activation, HIV infection is still associated with a remarkably high level of biomarkers of immune activation. Paradoxically, the expansion of immune suppressor cells during HIV infection can suppress potent anti-viral immune responses, which in turn contribute to viral persistence and disease progression. This indicates that HIV hijacks not only immune activation but also the immune regulatory responses to its advantage. In this work, we aim to pave the way to comprehend how such unwanted expansion of MDSCs could participate in the pathology of acute/primary and chronic HIV infection in humans, as well as simian immunodeficiency virus infection in rhesus macaques, according to the available literature.

scholarly journals Granulocytic Myeloid–Derived Suppressor Cells Increased in Early Phases of Primary HIV Infection Depending on TRAIL Plasma Level

2017 ◽  
Vol 74 (5) ◽  
pp. 575-582 ◽  
Author(s):  
Nicola Tumino ◽  
Maria T. Bilotta ◽  
Carmela Pinnetti ◽  
Adriana Ammassari ◽  
Andrea Antinori ◽  
...  
Keyword(s):  
Plasma Level ◽  
Hiv Infection ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Primary Hiv Infection ◽  
Early Phases

scholarly journals Expansion of a subset of CD14highCD16negCCR2low/negmonocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection

2012 ◽  
Vol 91 (5) ◽  
pp. 803-816 ◽  
Author(s):  
Lucio Gama ◽  
Erin N. Shirk ◽  
Julia N. Russell ◽  
Karina I. Carvalho ◽  
Ming Li ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

Myeloid-Derived Suppressor Cells Associated With Disease Progression in Primary HIV Infection

2017 ◽  
Vol 76 (2) ◽  
pp. 200-208 ◽  
Author(s):  
Zi-Ning Zhang ◽  
Nan Yi ◽  
Tong-Wei Zhang ◽  
Le-Le Zhang ◽  
Xian Wu ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Disease Progression ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Primary Hiv Infection
Sign in / Sign up

Export Citation Format

Share Document