To what extent does increased dietary fiber improve glucose and lipid metabolism in patients with noninsulin-dependent diabetes mellitus (NIDDM)?

1986 ◽  
Vol 43 (1) ◽  
pp. 16-24 ◽  
Author(s):  
C B Hollenbeck ◽  
A M Coulston ◽  
G M Reaven
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Dietary Fiber ◽  
Dependent Diabetes Mellitus ◽  
Glucose And Lipid Metabolism

Antihypertensive and vasculo- and renoprotective effects of pioglitazone in genetically obese diabetic rats

1997 ◽  
Vol 272 (6) ◽  
pp. E989-E996 ◽  
Author(s):  
T. Yoshimoto ◽  
M. Naruse ◽  
M. Nishikawa ◽  
K. Naruse ◽  
A. Tanabe ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Lipid Metabolism ◽  
Insulin Dependent Diabetes Mellitus ◽  
Sodium Balance ◽  
Dependent Diabetes Mellitus ◽  
Wall Thickening ◽  
Glomerular Injury ◽  
Glucose And Lipid Metabolism ◽  
Renal Complications

Although an improvement of insulin sensitivity has been shown to be a new therapeutic approach for treating diabetes mellitus, details of effects of this treatment on the cardiovascular system and possible renal complications remain unknown. In the present study, we investigated the effects of a thiazolidine derivative, pioglitazone, and examined the insulin-sensitizing action on blood pressure, nephropathy, and vascular changes in genetically obese diabetic Wistar fatty (WF) rats. Pioglitazone (3 mg.kg-1.day-1) was orally administered for 13 wk starting at the age of 5 wk, and the results were compared with those of vehicle-treated WF rats. At the age of 18 wk, vehicle-treated WF rats were associated with mild hypertension, nephropathy with proteinuria histological glomerular injury, and renal arteriolosclerosis in addition to hyperglycemia, hyperinsulinemia, and hyperlipidemia. Treatment with pioglitazone significantly improved glucose and lipid metabolism. In addition, it lowered blood pressure, decreased proteinuria, and prevented glomerular injury, renal arteriolosclerosis, and aortic medial wall thickening, whereas body weight, food intake, sodium balance, and urinary norepinephrine excretion were significantly increased. These results suggest that the insulin-sensitizing agent pioglitazone is effective in correcting not only glucose and lipid metabolism but also cardiovascular and renal complications in non-insulin-dependent diabetes mellitus.

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