Chemical Methods for the Determination of Clinical Vitamin C (Ascorbic Acid) Deficiency

1940 ◽  
Vol 10 (12) ◽  
pp. 882-893 ◽  
Author(s):  
George J. Kastlin ◽  
C. G. King ◽  
Clara R. Schlesinger ◽  
J. West Mitchell
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Chemical Methods ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency

scholarly journals The effect of scurvy on glycosaminoglycans of granulation tissue and costal cartilage

1968 ◽  
Vol 110 (4) ◽  
pp. 609-616 ◽  
Author(s):  
I. Antonowicz ◽  
E. Kodicek
Keyword(s):  
Ascorbic Acid ◽  
Granulation Tissue ◽  
Guinea Pigs ◽  
Costal Cartilage ◽  
Absolute Amount ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency ◽  
And Cartilage

1. The effect of ascorbic acid deficiency on glycosaminoglycans of granulation tissue and cartilage of guinea pigs was investigated by determination of the changes in the glucosamine and galactosamine contents 12 days after tendonectomy. 2. In normal granulation tissue, the glucosamine and galactosamine contents rose to a peak at 5 and 10 days respectively, whereas the hydroxyproline and proline contents continued to rise throughout the 20 days after tendonectomy. 3. The galactosamine in scorbutic granulation tissue, but not in that of pair-fed controls, decreased significantly in absolute amount and relatively to glucosamine, which remained practically unchanged; the cartilage galactosamine did not decrease during the 22 days of deficiency owing to the presence of excess of preformed galactosaminoglycans, which masked the small amount of newly formed glycosaminoglycans. 4. The chemical results were confirmed by radioactivity studies in vivo of incorporation of [U−14C]glucose into galactosamine and glucosamine of scorbutic granulation tissue and cartilage. The incorporation of 14C into galactosamine decreased significantly in scurvy in both tissues. 5. The results indicated in both tissues a decreased formation of galactosamine during scurvy, although an increased degradation of polymerized glycosaminoglycans could not be entirely ruled out. It is concluded that, if lack of ascorbic acid causes an impaired galactosamine formation, the most likely position for the block may be in the UDP-N-acetylglucosamine 4-epimerase reaction.

EXPERIMENTAL ATHEROSCLEROSIS WITH ASCORBIC ACID DEFICIENCY

1971 ◽  
Vol 35 (12) ◽  
pp. 1559-1565 ◽  
Author(s):  
TAKAO FUJITANI ◽  
KOTA OKADO ◽  
KATSUJI SENDA ◽  
MUNEAKI SUGIMURA ◽  
MOTOAKI KISHIKAWA
Keyword(s):  
Ascorbic Acid ◽  
Experimental Atherosclerosis ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency

Ascorbic Acid Deficiency —

1981 ◽  
Vol 5 (6) ◽  
pp. 531-532 ◽  
Author(s):  
R.E. Hodges ◽  
J.E. Canham ◽  
J.L. Smith
Keyword(s):  
Ascorbic Acid ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency

Effect of ascorbic acid deficiency on primary and reparative dentinogenesis in non-ascorbate-synthesizing ods rats

1997 ◽  
Vol 42 (10-11) ◽  
pp. 695-704 ◽  
Author(s):  
Motonari Ogawara ◽  
Kazuhiro Aoki ◽  
Takashi Okiji ◽  
Hideaki Suda
Keyword(s):  
Ascorbic Acid ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency
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