ODor-evoked Autobiographical Memory in Alzheimer’s disease?

2021 ◽  
Author(s):  
Mohamad El Haj
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autobiographical Memory ◽  
Personal Information ◽  
Disease Model ◽  
Olfactory Stimulation ◽  
Autobiographical Memories ◽  
Comprehensive Overview ◽  
Memory Decline ◽  
Stimulation Of

Abstract Objective Because memory decline is the hallmark of Alzheimer’s disease (AD), an important endeavor for both clinicians and researchers is to improve memory performances in AD. This can be pursued by olfactory stimulation of memory in patients with AD and by studying the effects of olfactory stimulation on autobiographical memory (i.e., memory for personal information). The effects of olfactory stimulation on autobiographical memory in patients with mild AD have been reported by recent research. We thus provide the first comprehensive overview of research on odor-evoked autobiographical memory in AD. We also establish the basis for solid theoretical analysis concerning the memory improvement reported by research on odor-evoked autobiographical memory in AD. Method We examined literature on odor-evoked autobiographical memories in AD and propose the “OdAMA” (Odor-evoked Autobiographical Memory in Alzheimer’s disease) model. Results and discussion According to OdAMA model, odor exposure activates involuntary access to specific autobiographical memories, which promotes enhanced experience subjective of retrieval in patients with AD and improves their ability to construct not only recent and remote events but also future ones. The OdAMA model could serve as a guide for researchers and clinicians interested in odor-evoked autobiographical memory in AD.

scholarly journals Autobiographical memory decline in Alzheimer’s disease, a theoretical and clinical overview

2015 ◽  
Vol 23 ◽  
pp. 183-192 ◽  
Author(s):  
Mohamad El Haj ◽  
Pascal Antoine ◽  
Jean Louis Nandrino ◽  
Dimitrios Kapogiannis
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autobiographical Memory ◽  
Memory Decline ◽  
Clinical Overview

Effects of olfactory stimulation on autobiographical memory in Alzheimer's disease

2018 ◽  
Vol 16 (3) ◽  
pp. 311-320 ◽  
Author(s):  
Ophélie Glachet ◽  
Marie-Charlotte Gandolphe ◽  
Karim Gallouj ◽  
Pascal Antoine ◽  
Mohamad El Haj
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autobiographical Memory ◽  
Olfactory Stimulation

Meloxicam-loaded nanocapsules as an alternative to improve memory decline in an Alzheimer’s disease model in mice: involvement of Na+, K+-ATPase

2016 ◽  
Vol 31 (4) ◽  
pp. 793-802 ◽  
Author(s):  
Francine R. Ianiski ◽  
Catiane B. Alves ◽  
Carla F. Ferreira ◽  
Virginia C. Rech ◽  
Lucielli Savegnago ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Model ◽  
Memory Decline

scholarly journals Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer’s Disease Model

Cell Reports ◽  
2016 ◽  
Vol 17 (7) ◽  
pp. 1819-1831 ◽  
Author(s):  
Yang Shen ◽  
Min Tian ◽  
Yuqiong Zheng ◽  
Fei Gong ◽  
Amy K.Y. Fu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Synaptic Plasticity ◽  
Disease Model ◽  
Stimulation Of

Self-defining Memories and their Contribution to the Sense of Self in Alzheimer’s Disease

2020 ◽  
Vol 17 (6) ◽  
pp. 508-516
Author(s):  
Mohamad EL Haj ◽  
Philippe Allain
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autobiographical Memory ◽  
Personal Information ◽  
Sense Of Self ◽  
Emotional Valence ◽  
The Way

Aims: Unlike autobiographical memory (i.e., memory for personal information) in Alzheimer’s Disease (AD), little is known about Self-Defining Memories (SDM) (i.e., memories of highly significant personal events) in AD. Methods: The characteristics of self-defining memories in AD were evaluated by analyzing their specificity, emotional valence, and integration, as well as their centrality and contribution to self-continuity. Results demonstrated fewer specific SDM in AD participants than in controls. Results: No significant differences were observed between AD participants and controls regarding the production of positive or integrated SDM. Furthermore, no significant differences were observed between AD participants and controls regarding the rating of the centrality of SDM and their contribution to self-continuity. These results demonstrate that, although AD participants produce fewer specific SDM than controls, both populations have similar levels of emotional valence, integration, centrality, and selfcontinuity of these memories. Conclusion: It is concluded that patients with AD, at least those in the mild stages of the disease, can build on significant personal events and experiences (i.e., SDM) to reflect on how these events have changed the way they see themselves.

Are Deficits in Social Cognition Linked to Autobiographical Memory in Patients with Alzheimer’s Disease?

2016 ◽  
Vol 27 (4) ◽  
pp. 257-264 ◽  
Author(s):  
Johannes H. Scheidemann ◽  
Franz Petermann ◽  
Marc Schipper
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Cognition ◽  
Theory Of Mind ◽  
Autobiographical Memory ◽  
Positive Relationship ◽  
Neuropsychological Test ◽  
Clinical Group ◽  
Neuropsychological Test Battery ◽  
Fluency Task

Abstract. We investigated theory of mind (ToM) deficits in Alzheimer‘s disease (AD) and its possible connection to autobiographical memory (ABM). Patients and matched controls were evaluated and compared using a video-based ToM test, an autobiographical fluency task, and a neuropsychological test battery. We found that ToM deficits were positively associated with semantic ABM in the clinical group, whereas a positive relationship appeared between ToM and episodic ABM in controls. We hypothesize that this reflects the course of the disease as well as that semantic ABM is used for ToM processing, being still accessible in AD. Furthermore, we assume that it is also less efficient, which in turn leads to a specific deficit profile of social cognition.

Research of autobiographical memory: The Autobiographical Interview (AI) Method (Healthy memory and Alzheimer’s disease)

2011 ◽  
Vol 66 (4) ◽  
pp. 587-603 ◽  
Author(s):  
Ágnes Szőllősi ◽  
Anikó Kónya
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autobiographical Memory

Levine, Svoboda és munkatársai (2002) olyan félig strukturált Önéletrajzi Interjút fejlesztettek ki az egyedi, specifikus önéletrajzi emlékek vizsgálatára, amely képes kiemelni az emlék elbeszéléséből az eseményspecifikus tartalmakat. Jelen vizsgálat célja e módszer magyar nyelvű adaptációja. Az eljárás segítségével három egészséges életkori csoport került összehasonlításra: fiatalok (20–27 év: 25 fő), középkorúak (45–55 év: 25 fő) és idősek (60–79 év: 16 fő), valamint egy emlékezetsérült klinikai betegcsoport: kezdeti stádiumú Alzheimer-kórban szenvedő betegek (60–80 év: 16 fő). Megerősítést kapott, hogy egészséges személyeknél a kor előrehaladtával romlik az önéletrajzi események elbeszélésének epizodikus gazdagsága. Továbbá, hogy az Alzheimer-kór kezdeti stádiumában sokkal nagyobb mértékben sérül az epizodikus emlékezés képessége, mint hasonló életkorú egészséges idős személyeknél.

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